Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma?
Anne Kotaniemi-Syrjänen,Raija Vainionpää,Tiina M. Reijonen,Matti Waris,Kaj Korhonen,Matti Korppi +5 more
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The results present rhinoviruses as important inducers of wheezing even in infancy and call for reevaluation of the role of rhinOViruses in the development of asthma.Abstract:
Background: Although known as common causes of upper respiratory infections, rhinoviruses, enteroviruses, and corona-viruses are poorly studied as inducers of wheezing in infants, and their possible role in the development of childhood asthma has not been investigated. Objective: The purposes of this study were to assess the occurrence of RV, enterovirus, and coronavirus infections in wheezing infants and to evaluate the association of these viral findings with early school-age asthma. Methods: In 1999, outcome in relation to asthma was studied in 82 of 100 initially recruited children who had been hospitalized for wheezing in infancy during the period 1992-1993. In 2000, etiologic viral studies regarding the index episode of wheezing were supplemented by rhinovirus, enterovirus, and coronavirus detection by RT-PCR from frozen nasopharyngeal aspirates in 81 of the children for whom adequate samples were available. Of these children, 66 had participated in the follow-up in 1999. Results: Rhinoviruses were identified in 27 (33%) of the 81 children, enteroviruses in 10 (12%), and coronaviruses in none. Rhinoviruses were present as single viral findings in 22 (81%) of the 27 rhinovirus-positive cases, and rhinovirus infections were associated with the presence of atopic dermatitis in infancy. Enteroviruses were commonly encountered in mixed infections and had no association with atopy. As single viral findings, rhinoviruses were associated with the development of asthma ( P = .047; odds ratio, 4.14; 95% CI, 1.02-16.77 versus rhinovirus-negative cases [by logistic regression adjusted for age, sex, and atopic dermatitis on entry)]. Conclusion: Our results present rhinoviruses as important inducers of wheezing even in infancy. The association with atopy and subsequent asthma calls for reevaluation of the role of rhinoviruses in the development of asthma. (J Allergy Clin Immunol 2003;111:66-71.)read more
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Journal ArticleDOI
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Daniel J. Jackson,Ronald E. Gangnon,Michael D. Evans,Kathy A. Roberg,Elizabeth L. Anderson,Tressa Pappas,Magnolia C. Printz,Wai Ming Lee,Peter Shult,Erik Reisdorf,Kirsten T. Carlson-Dakes,L.E.P. Salazar,Douglas F. DaSilva,Christopher J. Tisler,James E. Gern,Robert F. Lemanske +15 more
TL;DR: Among outpatient viral wheezing illnesses in infancy and early childhood, those caused by RV infections are the most significant predictors of the subsequent development of asthma at age 6 years in a high-risk birth cohort.
Journal ArticleDOI
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
Merci Kusel,Nicholas de Klerk,Tatiana Kebadze,Vaike Vohma,Patrick G. Holt,Sebastian L. Johnston,Peter D. Sly +6 more
TL;DR: Data suggest viral infections interact with atopy in infancy to promote later asthma, and protection of “high-risk” children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention.
Journal ArticleDOI
Rhinovirus illnesses during infancy predict subsequent childhood wheezing
R.F. Lemanske,Daniel J. Jackson,Ronald E. Gangnon,Michael D. Evans,Zhanhai Li,Peter Shult,Carol J. Kirk,Erik Reisdorf,Kathy A. Roberg,Elizabeth L. Anderson,Kirstin T Carlson-Dakes,Kiva J. Adler,Stephanie Gilbertson-White,Tressa Pappas,Douglas F. DaSilva,Christopher J. Tisler,James E. Gern +16 more
TL;DR: In this population of children at increased risk of developing allergies and asthma, the most significant risk factor for the development of preschool childhood wheezing is the occurrence of symptomatic rhinovirus illnesses during infancy that are clinically and prognostically informative based on their seasonal nature.
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Remodeling in asthma
TL;DR: Airway remodeling encompasses the structural alterations in asthmatic compared with normal airways, and is assumed to result in persistent airflow limitation, a decrease in lung function, and airway hyperresponsiveness.
Journal ArticleDOI
Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma
Minal Çalışkan,Yury A. Bochkov,Eskil Kreiner-Møller,Klaus Bønnelykke,Michelle M. Stein,Gaixin Du,Hans Bisgaard,Daniel J. Jackson,James E. Gern,R.F. Lemanske,Dan L. Nicolae,Carole Ober +11 more
TL;DR: Variants at the 17q21 locus were associated with asthma in children who had had HRV wheezing illnesses and with expression of two genes at this locus.
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Fernando D. Martinez,Anne L. Wright,Lynn M. Taussig,Catharine J. Holberg,Marilyn Halonen,Wayne J. Morgan +5 more
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A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.
Donald E. Staunton,Vincent J. Merluzzi,Robert Rothlein,Randall W. Barton,Steven D. Marlin,Timothy A. Springer +5 more
TL;DR: Identity between the receptor for the major group of rhinoviruses and ICAM-1 is demonstrated, suggesting that the host immune response to rh inovirus may facilitate spread to uninfected cells.