Journal ArticleDOI
Rift Valley fever virus.
Ramon Flick,Michèle Bouloy +1 more
TLDR
Recent advances in Rift Valley fever virus, its epidemiology, molecular biology and focus on recent data on the interactions between viral and cellular proteins, which help to understand the molecular mechanisms utilized by the virus to circumvent the host cellular response.Abstract:
Rift Valley fever is considered to be one of the most important viral zoonoses in Africa. In 2000, the Rift valley fever virus spread to the Arabian Peninsula and caused two simultaneous outbreaks in Yemen and Saudi Arabia. It is transmitted to ruminants and to humans by mosquitoes. The viral agent is an arbovirus, which belongs to the Phlebovirus genus in the Bunyaviridae family. This family of viruses comprises more than 300 members grouped into five genera: Orthobunyavirus, Phlebovirus, Hantavirus, Nairovirus, and Tospovirus. Several members of the Bunyaviridae family are responsible for fatal hemorrhagic fevers: Rift Valley fever virus (Phlebovirus), Crimean-Congo hemorrhagic fever virus (Nairovirus), Hantaan, Sin Nombre and related viruses (Hantavirus), and recently Garissa, now identified as Ngari virus (Orthobunyavirus). Here are reviewed recent advances in Rift Valley fever virus, its epidemiology, molecular biology and focus on recent data on the interactions between viral and cellular proteins, which help to understand the molecular mechanisms utilized by the virus to circumvent the host cellular response.read more
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Journal ArticleDOI
Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention
TL;DR: This review presents the latest advances in RVF virus research and explains why safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.
Journal ArticleDOI
Rift Valley fever virus
TL;DR: R Rift Valley fever epizootics and epidemics can rapidly overwhelm the capacities of the public health and veterinary medical communities to provide rapid diagnostic testing and adequate medical care for affected humans and other animals, which can number in the tens of thousands.
Journal ArticleDOI
Health risks at the Hajj
TL;DR: The response of clinicians, the Saudi Ministry of Health, and Hajj authorities to these unique problems are examined, and health recommendations for prospective pilgrims are listed.
Journal ArticleDOI
The Pathogenesis of Rift Valley Fever
Tetsuro Ikegami,Shinji Makino +1 more
TL;DR: The pathology of RVF in human patients and several animal models is described, and the role of viral virulence factors and host factors that affect RVFV pathogenesis are summarized.
Journal ArticleDOI
Applications of gold nanoparticles in virus detection.
TL;DR: The applications of AuNPs in virus testing and detection are reviewed, with a special focus on the applied types of bio-AuNP hybrid structures, virus detection targets, and assay modalities and formats.
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