Journal ArticleDOI
Risk factors for fragility fractures in type 1 diabetes.
Giulia Leanza,Ernesto Maddaloni,Dario Pitocco,Caterina Conte,Andrea Palermo,Anna Rita Maurizi,Angelo Lauria Pantano,Concetta Suraci,Maria Altomare,Rocky Strollo,Silvia Manfrini,Paolo Pozzilli,Ann V. Schwartz,Nicola Napoli,Nicola Napoli +14 more
TLDR
Poor glycemic control and long exposure to the disease are independent diabetes-related risk factors for multiple bone fractures in T1D.About:
This article is published in Bone.The article was published on 2019-08-01. It has received 44 citations till now.read more
Citations
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Journal ArticleDOI
Impact of Diabetes Mellitus on Bone Health.
TL;DR: The best available literature on the impact of diabetes mellitus on bone health in vitro and in vivo is summarised with an emphasis on future translational research opportunities in this field.
Journal ArticleDOI
Bone fragility in diabetes: novel concepts and clinical implications
TL;DR: In this paper , the authors discuss how the bone microenvironment responds to type 1 and type 2 diabetes and the mechanisms underlying fragility fractures, and discuss current and future therapeutic approaches that protect bone health in people with diabetes.
Journal ArticleDOI
Bone health in diabetes and prediabetes.
Silvia Costantini,Caterina Conte +1 more
TL;DR: Aim of this review is to provide a comprehensive overview of bone health and the mechanisms responsible for increased susceptibility to fracture across the spectrum of glycemic status, spanning from insulin resistance to overt forms of diabetes.
Journal ArticleDOI
Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes
Praveer Sihota,Ram Naresh Yadav,Ruban Dhaliwal,Jagadeesh Chandra Bose,Vandana Dhiman,Deepak Neradi,Shailesh Karn,Sidhartha Sharma,Sameer Aggarwal,Vijay Goni,Vishwajeet Mehandia,Deepak Vashishth,Sanjay Kumar Bhadada,Navin Kumar +13 more
TL;DR: In this article, the role of T2D in altering biomechanical, micro-structural, and compositional properties of bone in individuals with fragility fracture was investigated, for the first time, reports on alterations in bone tissue's material properties obtained from individuals with diabetes.
Journal ArticleDOI
Bone fragility in diabetes: novel concepts and clinical implications.
Lorenz C. Hofbauer,Björn Busse,Richard Eastell,Serge Ferrari,Morten Frost,Ralph Müller,Andrea M. Burden,Fernando Rivadeneira,Nicola Napoli,Martina Rauner +9 more
TL;DR: This Review summarises how the bone microenvironment responds to type 1 and type 2 diabetes, and the mechanisms underlying fragility fractures, and describes the value of novel imaging technologies and the clinical utility of biomarkers.
References
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Journal ArticleDOI
Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.
TL;DR: A meta-regression showed that body mass index (BMI) was a major determinant for BMD in both the spine and hip and the increase in fracture risk in T1D and T2D was increased and BMD lower in patients with complications to diabetes.
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Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012
Elizabeth J. Mayer-Davis,Jean M. Lawrence,Dana Dabelea,Jasmin Divers,Scott Isom,Lawrence M. Dolan,Giuseppina Imperatore,Barbara Linder,Santica M. Marcovina,David J. Pettitt,Catherine Pihoker,Sharon Saydah,Lynne E. Wagenknecht +12 more
TL;DR: The incidences of both type 1 and type 2 diabetes among youths increased significantly in the 2002–2012 period, particularly among youths of minority racial and ethnic groups.
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Systematic Review of Type 1 and Type 2 Diabetes Mellitus and Risk of Fracture
Mohsen Janghorbani,Mohsen Janghorbani,Rob M. van Dam,Walter C. Willett,Walter C. Willett,Frank B. Hu,Frank B. Hu +6 more
TL;DR: An association between both type 1 and type 2 diabetes and increased risk of hip fracture in men and women and between studies conducted in the United States and Europe is supported.
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Mechanisms of diabetes mellitus-induced bone fragility
TL;DR: Factors including treatment-induced hypoglycaemia, certain antidiabetic medications with a direct effect on bone and mineral metabolism, as well as an increased propensity for falls, all contribute to the increased fracture risk in patients with diabetes mellitus.
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Risk of Subsequent Fracture After Low-Trauma Fracture in Men and Women
TL;DR: After an initial low-trauma fracture, absolute risk of subsequent fracture was similar in women and men and at least as great as the initial fracture risk for a woman 10 years older.