Risk Factors for Severe COVID-19 in Children.
Kelly Graff,Christiana Smith,Lori J. Silveira,Sarah Jung,Shane Curran-Hays,Jane Jarjour,Lauren Carpenter,Kasey Pickard,Michael Mattiucci,JoEllen Fresia,Elizabeth J. McFarland,Samuel R. Dominguez,Samuel R. Dominguez,Lisa Abuogi +13 more
TLDR
Extremes of age, comorbid conditions, and elevated CRP are predictors of severe disease in children.Abstract:
Background There are limited pediatric data regarding severe COVID-19 disease. Our study aims to describe the epidemiology and identify risk factors for severe COVID-19 disease in children. Methods This is a retrospective cohort study among children with positive SARS-CoV-2 PCR from March to July 2020 at Children's Hospital Colorado. Risk factors for severe disease were analyzed as defined by hospital admission, respiratory support, or critical care. Univariable and multivariable analyses were conducted. Results Among 454 patients identified with SARS-CoV-2, 191 (42.1%) were females, median age 11 years. Fifty-five percent of all patients identified as Hispanic compared with 29% among all hospital visits in 2019 (P 20 years [adjusted odds ratio (aOR), 7.85; P 20 years, asthma, gastrointestinal condition, and similar symptoms at presentation were also predictors for respiratory support. Elevated C-reactive protein was associated with the need for critical care with median of 17.7 mg/dL (IQR, 5.3-22.9) versus 1.95 mg/dL (IQR, 0.7-5.5) among patients requiring critical versus no critical care (OR, 1.2; P = 0.02). Conclusions Extremes of age, comorbid conditions, and elevated CRP are predictors of severe disease in children. Findings from this study can inform pediatric providers and public health officials to tailor clinical management, pandemic planning, and resource allocation.read more
Citations
More filters
Journal ArticleDOI
Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children.
Lyudmyla Kompaniyets,Nickolas T. Agathis,Jennifer M. Nelson,Jennifer M. Nelson,Leigh Ellyn Preston,Jean Y. Ko,Jean Y. Ko,Brook Belay,Audrey F. Pennington,Melissa L. Danielson,Carla L. DeSisto,Jennifer R Chevinsky,Lyna Z. Schieber,Hussain R. Yusuf,James Baggs,William R. Mac Kenzie,William R. Mac Kenzie,Karen K. Wong,Karen K. Wong,Tegan K. Boehmer,Tegan K. Boehmer,Adi V. Gundlapalli,Alyson B. Goodman,Alyson B. Goodman +23 more
TL;DR: In this paper, the authors examined the risk of severe COVID-19 illness among children associated with underlying medical conditions and medical complexity and found that the strongest risk factors for hospitalization were type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity.
Journal ArticleDOI
Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality
TL;DR: In this paper , the authors highlight the clinical evidence supporting the rationale for the risk and protective factors for the morbidity, severity, and mortality of COVID-19 in children.
Journal ArticleDOI
Which children and young people are at higher risk of severe disease and death after hospitalisation with SARS-CoV-2 infection in children and young people: A systematic review and individual patient meta-analysis
Rachel Harwood,Helen Yan,Nish Talawila Da Camara,Clare Ruth Smith,Joseph L Ward,Catrin Tudur-Smith,Mike. Linney,Matthew Clark,Elizabeth Whittaker,Defne Saatci,Peter G Davis,Karen Luyt,Elizabeth S Draper,Simon E. Kenny,Lorna K Fraser,Russell M Viner +15 more
TL;DR: In this paper , a systematic review and individual patient meta-analysis was conducted to describe pre-existing factors associated with severe disease, primarily admission to critical care, and death secondary to SARS-CoV-2 infection in hospitalised children and young people.
Journal ArticleDOI
Risk Factors for Severe COVID-19 in Children: A Systematic Review and Meta-Analysis
TL;DR: Children with comorbidities such as obesity, diabetes, heart disease, chronic lung diseases other than asthma, seizure disorders, and an immunocompromised status had a high prevalence of severe COVID-19.
Journal ArticleDOI
Vaccines for COVID-19: Where do we stand in 2021?
Ketaki Sharma,Archana Koirala,Katrina Nicolopoulos,Clayton Chiu,Nicholas Wood,Philip N Britton,Philip N Britton +6 more
TL;DR: A small number of countries have approved a COVID-19 vaccine for use in adolescents or children, but only 0.9% of the people in low-income countries have received at least one dose of a vaccine as discussed by the authors.
References
More filters
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Epidemiology of COVID-19 Among Children in China.
Yuanyuan Dong,Xi Mo,Yabin Hu,Xin Qi,Fang Jiang,Zhongyi Jiang,Shilu Tong,Shilu Tong,Shilu Tong +8 more
TL;DR: The distribution of children’s COVID-19 cases varied with time and space, and most of the cases were concentrated in Hubei province and surrounding areas, providing strong evidence of human-to-human transmission.
Journal ArticleDOI
Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020.
Shikha Garg,Shikha Garg,Lindsay Kim,Michael Whitaker,Alissa O’Halloran,Charisse N Cummings,Rachel Holstein,Mila M. Prill,Shua J Chai,Pam Daily Kirley,Nisha B Alden,Breanna Kawasaki,Kimberly Yousey-Hindes,Linda M. Niccolai,Evan J. Anderson,Evan J. Anderson,Kyle P Openo,Andrew Weigel,Maya Monroe,Patricia Ryan,Justin Henderson,Sue Kim,Kathy Como-Sabetti,Ruth Lynfield,Daniel M. Sosin,Salina Torres,Alison Muse,Nancy M. Bennett,Laurie M Billing,Melissa Sutton,Nicole West,William Schaffner,H. Keipp Talbot,Clarissa Aquino,Andrea George,Alicia P Budd,Lynnette Brammer,Gayle E Langley,Aron J. Hall,Alicia M. Fry +39 more
TL;DR: It is suggested that older adults have elevated rates of COVID-19-associated hospitalization and the majority of persons hospitalized with CO VID-19 have underlying medical conditions, which underscore the importance of preventive measures to protect older adults and persons with underlyingmedical conditions, as well as the general public.
Journal ArticleDOI
SARS-CoV-2 Infection in Children.
Xiaoxia Lu,Liqiong Zhang,Hui Du,Jingjing Zhang,Yuan Y. Li,Jingyu Qu,Wenxin Zhang,Youjie Wang,Shuangshuang Bao,Ying Li,Chuansha Wu,Hongxiu Liu,Di Liu,Jianbo Shao,Xuehua Peng,Yonghong Yang,Zhisheng Liu,Yun Xiang,Furong Zhang,Rona M. Silva,Kent E. Pinkerton,Kunling Shen,Han Xiao,Shunqing Xu,Gary Wong +24 more
TL;DR: Investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years in SARS-CoV-2 Infection in Children.
Related Papers (5)
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.
Florian Götzinger,Begoña Santiago-García,Antoni Noguera-Julian,Miguel Lanaspa,Laura Lancella,Francesca Ippolita Calò Carducci,Natalia Gabrovska,Svetlana Velizarova,Petra Prunk,Veronika Osterman,Uros Krivec,Andrea Lo Vecchio,Delane Shingadia,Delane Shingadia,Antoni Soriano-Arandes,Susana Melendo,Marcello Lanari,Luca Pierantoni,Noémie Wagner,Arnaud G L'Huillier,Ulrich Heininger,Nicole Ritz,Nicole Ritz,Srini Bandi,Nina Krajcar,Srđan Roglić,Mar Santos,Christelle Christiaens,Marine Creuven,Danilo Buonsenso,Steven B. Welch,Matthias Bogyi,Folke Brinkmann,Marc Tebruegge,Marc Tebruegge,Marc Tebruegge,Jasmin Pfefferle,Angela Zacharasiewicz,Angelika Berger,Roland Berger,Volker Strenger,Daniela S. Kohlfürst,Anna Zschocke,Benoît Bernar,Burkhard Simma,Edda Haberlandt,Christina Thir,Ariane Biebl,Koen Vanden Driessche,Tine Boiy,Daan Van Brusselen,An Bael,Sara Debulpaep,Petra Schelstraete,Ivan Pavic,Ulrikka Nygaard,Jonathan P. Glenthoej,Lise Heilmann Jensen,Ilona Lind,Mihhail Tistsenko,Ulle Uustalu,Laura Buchtala,Stephanie Thee,Robin Kobbe,Cornelius Rau,Nicolaus Schwerk,Michael Barker,Maria Tsolia,Irini Eleftheriou,Patrick Gavin,Oksana Kozdoba,Borbàla Zsigmond,Piero Valentini,Piero Valentini,Inga Ivaškeviciene,Rimvydas Ivaškevicius,Valentina Vilc,Elisabeth Schölvinck,Astrid Rojahn,Anastasios Smyrnaios,Claus Klingenberg,Isabel Carvalho,Andreia Ribeiro,Anna Starshinova,Ivan Solovic,Lola Falcón,Olaf Neth,Laura Minguell,Matilde Bustillo,Aida M. Gutiérrez-Sánchez,Borja Ibanez,Francesc Ripoll,Beatriz Soto,Karsten Kötz,Petra Zimmermann,Hanna Schmid,Franziska Zucol,Anita Niederer,Michael Buettcher,Benhur Şirvan Çetin,Olga Bilogortseva,Vera Chechenyeva,Alicia Demirjian,Fiona Shackley,Lynne McFetridge,Lynne Speirs,Conor Doherty,Laura Jones,Paddy McMaster,Clare S. Murray,Frances Child,Yvonne Beuvink,Nick Makwana,Elisabeth Whittaker,Amanda Williams,Katy Fidler,Jolanta Bernatoniene,R Song,Zoe Oliver,Andrew Riordan +119 more
Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York.
Philip Zachariah,Philip Zachariah,Candace L Johnson,Candace L Johnson,Katia C Halabi,Danielle Ahn,Anita Sen,Avital M. Fischer,Sumeet L. Banker,Mirna Giordano,Christina S. Manice,Rebekah Diamond,Taylor B. Sewell,Adam J. Schweickert,John Babineau,R. Colin Carter,Daniel B. Fenster,Jordan S. Orange,Teresa A. McCann,Steven G. Kernie,Lisa Saiman,Lisa Saiman +21 more
Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1-July 25, 2020.
Lindsay Kim,Michael Whitaker,Alissa O’Halloran,Anita Kambhampati,Shua J Chai,Arthur Reingold,Isaac Armistead,Breanna Kawasaki,James Meek,Kimberly Yousey-Hindes,Evan J. Anderson,Evan J. Anderson,Kyle P Openo,Andy Weigel,Patricia Ryan,Maya Monroe,Kimberly Fox,Sue Kim,Ruth Lynfield,Erica Bye,Sarah Shrum Davis,Chad Smelser,Grant Barney,Nancy L Spina,Nancy M. Bennett,Christina B Felsen,Laurie M Billing,Jessica Shiltz,Melissa Sutton,Nicole West,H. Keipp Talbot,William Schaffner,Ilene Risk,Andrea Price,Lynnette Brammer,Alicia M. Fry,Aron J. Hall,Gayle E Langley,Shikha Garg,Shikha Garg,Covid-Net Surveillance Team +40 more