Journal ArticleDOI
Risk of Fatal and Near-Fatal Asthma in Relation to Inhaled Corticosteroid Use
Pierre Ernst,Walter O. Spitzer,Samy Suissa,Donald W. Cockcroft,Brian F. Habbick,Ralph I. Horwitz,Jean-Francois Boivin,Mary McNutt,A S Buist +8 more
TLDR
Data support recent guidelines from several countries that recommend the use of inhaled corticosteroids in moderate and severe asthma.Abstract:
Objective. —To examine the relationship between patterns of use of inhaled beclomethasone dipropionate and the risk of fatal and near-fatal asthma. Design. —Nested case-control analysis of a historical cohort; a further analysis. Setting. —The 12 301 residents of Saskatchewan aged 5 to 54 years who were dispensed 10 or more asthma drugs from 1978 to 1987. Patients. —The 129 persons who experienced asthma death (n=44) and near-death (n=85) and their 655 controls matched as to age and date of entry into the cohort, with the additional matching criteria of at least one hospitalization for asthma in the prior 2 years, region of residence, and having received social assistance. Main Outcome. —Life-threatening attacks of asthma defined as death due to asthma or the occurrence of hypercarbia, intubation, and mechanical ventilation during an acute attack of asthma. Results. —After accounting for the risk associated with use of other medications and adjustment for markers of risk of adverse events related to asthma, subjects who had been dispensed, on average, one or more metered-dose inhalers of beclomethasone per month over a 1-year period had a significantly lower risk of fatal and near-fatal asthma (odds ratio, 0.1; 95% confidence interval, 0.02 to 0.6). Conclusion.—These data support recent guidelines from several countries that recommend the use of inhaled corticosteroids in moderate and severe asthma. ( JAMA . 1992;268:3462-3464)read more
Citations
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Journal ArticleDOI
Global strategy for asthma management and prevention: GINA executive summary.
Eric D. Bateman,Suzanne S. Hurd,Peter J. Barnes,Jean Bousquet,Jeffrey M. Drazen,JM FitzGerald,Peter G. Gibson,K. Ohta,Paul M. O'Byrne,Søren Pedersen,Emilio Pizzichini,Sean D. Sullivan,Sally E. Wenzel,Heather J. Zar +13 more
TL;DR: It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions.
Journal ArticleDOI
European Resuscitation Council Guidelines for Resuscitation 2015
Gavin D. Perkins,Gavin D. Perkins,Anthony J. Handley,Rudolph W. Koster,Maaret Castrén,Michael Smyth,Theresa M. Olasveengen,Koenraad G. Monsieurs,Koenraad G. Monsieurs,Violetta Raffay,Jan-Thorsten Gräsner,Volker Wenzel,Giuseppe Ristagno,Jasmeet Soar,Leo Bossaert,Antonio Caballero,Pascal Cassan,Cristina Granja,Claudio Sandroni,David Zideman,Jerry P. Nolan,Ian Maconochie,Robert Greif +22 more
TL;DR: This chapter contains guidance on the techniques used during the initial resuscitation of an adult cardiac arrest victim and the use of an automated external defibrillator (AED).
Journal ArticleDOI
Low-dose inhaled corticosteroids and the prevention of death from asthma.
TL;DR: The regular use of low-dose inhaled corticosteroids is associated with a decreased risk of death from asthma and was higher than the rate among patients who continued to use the drugs.
Journal ArticleDOI
European Resuscitation Council Guidelines for Resuscitation 2015: Section 4. Cardiac arrest in special circumstances
Anatolij Truhlář,Charles D. Deakin,Jasmeet Soar,Gamal Eldin Abbas Khalifa,A. Alfonzo,Joost J.L.M. Bierens,Guttorm Brattebø,Hermann Brugger,Joel Dunning,Silvija Hunyadi-Anticevic,Rudolph W. Koster,David Lockey,Carsten Lott,Peter Paal,Gavin D. Perkins,Claudio Sandroni,Karl-Christian Thies,David Zideman,Jerry P. Nolan +18 more
TL;DR: The guidelines for resuscitation in special circumstances section Collaborators1 are published on behalf of the Cardiac arrest in special ircumstances section Collaborator1.
References
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N. E. Breslow,N. E. Day +1 more
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The Use of β-Agonists and the Risk of Death and near Death from Asthma
W O Spitzer,Samy Suissa,Pierre Ernst,Ralph I. Horwitz,Brian F. Habbick,Donald W. Cockcroft,Jean-Francois Boivin,M McNutt,A S Buist,A. S. Rebuck +9 more
TL;DR: The use ofβ-agonists administered by a metered-dose inhaler was associated with an increased risk of death from asthma and the regular use of β2-agonist bronchodilators.
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Regular inhaled beta-agonist treatment in bronchial asthma
Malcolm R. Sears,D R Taylor,Cristin G. Print,D C Lake,Q Q Li,E M Flannery,D M Yates,M K Lucas,G. P. Herbison +8 more
TL;DR: Regular inhalation of a beta-sympathomimetic agent was associated with deterioration of asthma control in the majority of subjects, suggesting that the trends to use of regular, higher doses or longer-acting inhaled beta-SympathomIMetic treatment may be an important causal factor in the worldwide increase in morbidity from asthma.
Journal ArticleDOI
Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma.
Tari Haahtela,Markku Järvinen,Tuomo Kava,Kirsti Kiviranta,Sirkka Koskinen,Kaarina Lehtonen,Kurt Nikander,Tore Persson,Kaija Reinikainen,Olof Selroos,Anssi Sovijärvi,Brita Stenius-Aarniala,Thore Svahn,Ritva Tammivaara,Lauri A. Laitinen +14 more
TL;DR: Antiinflammatory therapy with inhaled budesonide is an effective first-line treatment for patients with newly detected, mild asthma, and it is superior to the use of terbutaline in such patients.
Journal ArticleDOI
Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics.
Elizabeth F. Juniper,P A Kline,M A Vanzieleghem,E H Ramsdale,Paul M. O'Byrne,F. E. Hargreave +5 more
TL;DR: Regular, prolonged use of inhaled steroid can produce marked improvements in airway hyperresponsiveness, sometimes with full resolution, and these improvements are accompanied by clinically significant improvements in clinical asthma.