Journal ArticleDOI
The Use of β-Agonists and the Risk of Death and near Death from Asthma
W O Spitzer,Samy Suissa,Pierre Ernst,Ralph I. Horwitz,Brian F. Habbick,Donald W. Cockcroft,Jean-Francois Boivin,M McNutt,A S Buist,A. S. Rebuck +9 more
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The use ofβ-agonists administered by a metered-dose inhaler was associated with an increased risk of death from asthma and the regular use of β2-agonist bronchodilators.Abstract:
Background. Morbidity and mortality from asthma appear to be increasing, and it has been suggested that medications used to treat asthma are contributing to this trend. We investigated a possible association between death or near death from asthma and the regular use of β2-agonist bronchodilators. Methods. Using linked health insurance data bases from Saskatchewan, Canada, we conducted a matched case–control study of subjects drawn from a cohort of 12,301 patients for whom asthma medications had been prescribed between 1978 and 1987. We matched 129 case patients who had fatal or near-fatal asthma with 655 controls (who had received medications for asthma but had not had fatal or near-fatal events) with respect to region of residence, age, receipt of social assistance, and previous hospitalization for asthma. Results. The use of β-agonists administered by a metered-dose inhaler was associated with an increased risk of death from asthma (odds ratio, 2.6 per canister per month; 95 percent confidence...read more
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Journal ArticleDOI
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
Journal ArticleDOI
British guideline on the management of asthma: A national clinical guideline
Graham Douglas,Bernard Higgins,Neil Barnes,Anne Boyter,Sherwood Burge,Christopher J Cates,Gary Connett,Jon Couriel,Paul Cullinan,Sheila Edwards,Erica Evans,Monica Fletcher,Christopher E.M. Griffiths,Liam Heaney,Michele Hilton Boon,Steve Holmes,Ruth McArthur,C Nelson-Piercy,Martyn R Partridge,James Y. Paton,Ian D. Pavord,Elaine Carnegie,Hilary Pinnock,Safia Qureshi,Colin F. Robertson,Michael D. Shields,John O. Warner,John H. White +27 more
TL;DR: These guidelines have been replaced by British Guideline on the Management of Asthma.
Journal ArticleDOI
Low-dose inhaled corticosteroids and the prevention of death from asthma.
TL;DR: The regular use of low-dose inhaled corticosteroids is associated with a decreased risk of death from asthma and was higher than the rate among patients who continued to use the drugs.
References
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Statistical Methods in Cancer Research
TL;DR: Statistical methods in cancer research as mentioned in this paper, Statistical Methods in Cancer Research, Statistical methods in Cancer research, Statistical methods for cancer research, کتابخانه مرکزی دانشگاه علوم پزش
Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Journal ArticleDOI
Regular inhaled beta-agonist treatment in bronchial asthma
Malcolm R. Sears,D R Taylor,Cristin G. Print,D C Lake,Q Q Li,E M Flannery,D M Yates,M K Lucas,G. P. Herbison +8 more
TL;DR: Regular inhalation of a beta-sympathomimetic agent was associated with deterioration of asthma control in the majority of subjects, suggesting that the trends to use of regular, higher doses or longer-acting inhaled beta-SympathomIMetic treatment may be an important causal factor in the worldwide increase in morbidity from asthma.
Journal ArticleDOI
Prescribed fenoterol and death from asthma in new zealand, 1981-83; case-control study
TL;DR: Findings are consistent with the hypothesis that use of fenoterol by metered dose inhaler (MDI) increases the risk of death in severe asthma.
Journal ArticleDOI
Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: A comparison between budesonide and terbutaline
TL;DR: It is concluded that budesonide improves bronchial hyperreactivity, possibly by a dampening of late allergic reactions, whereas treatment with terbutaline may lead to a temporary increase of bronchia hyperreactive, possibly as a result of beta-receptor desensitization.