Role of thiols in oxidative stress.
Shahid P Baba,Aruni Bhatnagar +1 more
TLDR
Further elucidation of the relationship between changes in cell redox and thiol reactivity could provide a better understanding of how redox changes regulate cell function and how disruption of these relationships lead to tissue injury and dysfunction and the development of chronic diseases such as cancer and cardiovascular disease.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01 and is currently open access. It has received 105 citations till now. The article focuses on the topics: Oxidative stress & Glutathione.read more
Citations
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Journal ArticleDOI
Oxidative Stress and Hypertension
Kathy K. Griendling,Livia L Camargo,Francisco J. Rios,Rheure Alves-Lopes,Augusto C. Montezano,Rhian M. Touyz +5 more
TL;DR: A link between oxidative stress and hypertension has been established in multiple animal models of hypertension but remains elusive in humans while initial studies focused on inactivation of nitric oxide by superoxide, our understanding of relevant reactive oxygen species (superoxide, hydrogen peroxide, and peroxynitrite) and how they modify complex signaling pathways to promote hypertension has expanded significantly.
Journal ArticleDOI
Oxidative Stress: A Unifying Paradigm in Hypertension.
Rhian M. Touyz,Francisco J. Rios,Rheure Alves-Lopes,Karla B Neves,Livia L Camargo,Augusto C. Montezano +5 more
TL;DR: A unifying concept where oxidative stress is a common mediator underlying pathophysiologic processes in hypertension is provided, whereby ROS influence vascular function, aldosterone/mineralocorticoid actions, and immunoinflammation, all important processes contributing to the development of hypertension.
Journal ArticleDOI
Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans
TL;DR: The state of the art of knowledge about OS indexes for diagnosis of health or disease in humans is presented and it is suggested that all indexes analyzed allow diagnose and differentiate the OS related to human health and disease.
Journal ArticleDOI
Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes
Paul-Mihai Boarescu,Ioana Boarescu,Ioana Corina Bocșan,Raluca Maria Pop,Dan Gheban,Adriana Elena Bulboacă,Cristina Nicula,Ruxandra-Mioara Râjnoveanu,Sorana D. Bolboacă +8 more
TL;DR: Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation, and better prevent cardiomyocytes damage, and electrocardiogram alterations, in the case of ISO-induced MI in rats.
Journal ArticleDOI
Anionic Ln–MOF with tunable emission for heavy metal ion capture and L-cysteine sensing in serum
Tiancheng Sun,Ruiqing Fan,Rui Xiao,Tingfeng Xing,Mingyue Qin,Yaqi Liu,Sue Hao,Wei Chen,Yulin Yang +8 more
TL;DR: Wang et al. as discussed by the authors reported two sensitive luminescent probes based on a novel heterometallic anionic MOF, Eu-K-bpda (H2bpda = 2,2′-bipyridine-6,6′-dicarboxylic acid), for wide range L-cysteine detection in serum.
References
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Journal ArticleDOI
Radical-free biology of oxidative stress
TL;DR: Data is summarized supporting a complementary hypothesis for oxidative stress in disease that can occur without free radicals, which is that oxidative stress occurs as a consequence of disruption of thiol redox circuits, which normally function in cell signaling and physiological regulation.
Journal ArticleDOI
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
Takeshi Adachi,Robert M. Weisbrod,David R. Pimentel,Jia Ying,Victor S. Sharov,Christian Schöneich,Richard A. Cohen +6 more
TL;DR: In this paper, it was shown that NO-derived peroxynitrite (ONOO) directly increases SERCA activity by S-glutathiolation and that this modification of SERCA is blocked by irreversible oxidation of the relevant cysteine thiols during atherosclerosis.
Journal ArticleDOI
Redox state of glutathione in human plasma
TL;DR: Results suggest that E(h) values for GSSG/2GSH and CySS-mono-Gly/(CysGly) may provide useful means to quantitatively express the oxidant/antioxidant balance in clinical and epidemiologic studies.
Journal ArticleDOI
Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation
John J. Mieyal,John J. Mieyal,Molly Gallogly,Suparna Qanungo,Elizabeth A. Sabens,Elizabeth A. Sabens,Melissa D. Shelton,Melissa D. Shelton +7 more
TL;DR: A large number of proteins have been identified as potentially regulated by reversible S-glutathionylation, but only a few studies have documented glutathioneylation-dependent changes in activity of specific proteins in a physiological context.
Journal ArticleDOI
Regulation of PTP1B via glutathionylation of the active site cysteine 215.
William C. Barrett,J P DeGnore,Simone König,H M Fales,Yen Fang Keng,Zhong Yin Zhang,M B Yim,P B Chock +7 more
TL;DR: Glutathionylation of the cysteine sulfenic derivative will prevent the enzyme from further oxidation to its irreversible forms, and constitutes an efficient regulatory mechanism.
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Glutathione homeostasis and redox-regulation by sulfhydryl groups.
Andreas J. Meyer,Rüdiger Hell +1 more