Journal ArticleDOI
Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial.
Sheila M Wicks,Robin Tong,Chong-Zhi Wang,Michael O'Connor,Theodore Karrison,Shang Li,Jonathan Moss,Chun-Su Yuan +7 more
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TLDR
Although there were no obvious changes in CD4, CD8, and CD19 levels after the extract, CD56 cell count increased during the study and returned to baseline 10 days after the herbal intake, but due to relatively high variability and small sample size, this CD56 increase did not achieve statistical significance, and remains to be re-evaluated in the future.Abstract:
Ganoderma lucidum is a herbal medicine commonly used in oriental countries as a remedy for treating various medical conditions. In this controlled study, we evaluated the safety and tolerance of oral administration of Ganoderma lucidum in 16 human volunteers who received 2 grams of the extract or placebo twice daily for 10 consecutive days. During the study, information from subjective questionnaires were obtained, electrocardiograms, complete blood counts, blood chemistry analysis and urinalysis were performed. In addition, blood tests reflecting immunity were done. Our data showed that compared to placebo group, no adverse effects were observed after the extract intake. Although there were no obvious changes in CD4, CD8, and CD19 levels after the extract, CD56 cell count increased during the study and returned to baseline 10 days after the herbal intake. However, due to relatively high variability and small sample size, this CD56 increase did not achieve statistical significance, and remains to be re-evaluated in the future. It appears that an additional long-term safety and tolerance trial with herbal dose-escalating design is warranted.read more
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Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities.
TL;DR: This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved and suggests that the anti-tumor activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects.
Journal ArticleDOI
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.
Abdullah Shaito,Duong Thi Bich Thuan,Hoa Thi Phu,Thi Hieu Dung Nguyen,Hiba Hasan,Sarah Halabi,Samar Abdelhady,Gheyath K. Nasrallah,Ali H. Eid,Ali H. Eid,Gianfranco Pintus,Gianfranco Pintus +11 more
TL;DR: The employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed.
Journal ArticleDOI
Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells.
Li Ren,Jie Zhang,Tiehua Zhang +2 more
TL;DR: As an available adjunctive remedy, polysaccharides from Ganoderma can potentially be applied for the modulation of the host immune system, namely the innate immunity, the cellular immunity, and the humoral immunity.
Journal ArticleDOI
Potential role of ginseng in the treatment of colorectal cancer.
Chong-Zhi Wang,Chun-Su Yuan +1 more
TL;DR: This heat treatment process may increase the role of ginseng in treating colorectal cancer, and various steaming temperature and time treatment of the ginsENG herbs can change ginsenoside profiles, and enhance their anti-cancer activities.
Journal ArticleDOI
Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus
Yan Zhou,Ze-qiang Qu,Yuan-Shan Zeng,Yu-kun Lin,Yan Li,Peter Chung,Ricky W. K. Wong,Urban Hägg +7 more
TL;DR: Investigating if preadministration with GLS could alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), protect neurons from apoptosis, and improve cognitive dysfunction found it could protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ.
References
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Book
Chinese Herbal Medicine: Materia Medica
TL;DR: The therapeutic use of herbs and herbal medicines in the world s great traditional medical systems is guided by the principles and precepts of that system, generally speaking the standardized applications of chinese herbs began since the publishing of shang han lun.
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The Pharmacology of Chinese Herbs
TL;DR: Introduction A Brief History of Chinese Medicine The Cardiovascular System Herbs with Multiple Actions Cardiac Herbs Antiarrhythmic Herbs Antihypertensive Herbs antianginal Herbs antihypercholesteroliemic HerbsAntishock Herbs The Nervous System Anesthetics and Muscle-Relaxing Herbs Sedatives and Hypnotic Herps Anticonvulsive Herbs
Journal ArticleDOI
Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applications.
TL;DR: There is still an active body of opinion that would regard cancer as a parasitic disease due to infection of cells by extrinsic viruses, and any claim that all cancers are of infective character is unjustified and frankly absurd.
Journal ArticleDOI
The risk-benefit profile of commonly used herbal therapies : Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava
TL;DR: This article provides riskbenefit profiles for the most commonly used herbal medicines, based on systematic reviews of randomized clinical trials in humans, which suggest that ginkgo has antiedemic, antihypoxic, free radical-scavenging, antioxidant, metabolic, antiplatelet, hemorheologic, and microcirculatory actions.
Journal ArticleDOI
Commonly used herbal medicines in the United States: a review
TL;DR: Of the ten most commonly used herbs in the United States, systematic reviews have concluded that only four are likely to be effective, and there is very limited evidence to evaluate the efficacy of the approximately 20,000 other available herbal products.
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