Journal ArticleDOI
Scale-up of one-step synthesis of acacetin and apigenin using 915 MHz microwaves
TLDR
In this article, a liquid phase one-step synthesis of acacetin from ethyl 3-(4-methoxyphenyl)-3-oxopropionate and phloroglucinol using PEG 1000 as solvent was examined.Abstract:
In this work liquid phase one-step synthesis of acacetin from ethyl 3-(4-methoxyphenyl)-3-oxopropionate and phloroglucinol using PEG 1000 as solvent was examined. Heating of the reaction mixture was done with 915 MHz and 2.45 GHz microwaves at atmospheric pressure. The demethylation of the obtained acacetin using HBr at reflux led to the formation of apigenin. In view of a possible scale-up, the reaction conditions under 915 MHz microwaves were optimized to obtain high yields of acacetin. The energy required to convert phloroglucinol in acacetin was also estimated and used to calculate the total microwave power required for scaling up the process by a factor of 100. This method is an easier and cleaner synthesis for large scale preparation of flavones with good yields and purity.read more
Citations
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Journal ArticleDOI
Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders.
TL;DR: Acacetin is a potent molecule reported for its strong anti-inflammatory and anti-cancer activity, however further scientific evidence is essential to validate its potency in disease models associated with inflammation and cancer.
Journal ArticleDOI
Strategy to scale up microwave synthesis with insight into the thermal and non-thermal effects from energy-based perspective
Chung-Hung Chan,Najmi Izzuddin Ab Manap,Nik Siti Mariam Nek Mat Din,Ahmad Syafiq Ahmad Hazmi,Kien Woh Kow,Yong Kuen Ho +5 more
TL;DR: In this paper, a strategy to industrialize microwave synthesis from the perspectives of process optimization, scale up and reactor design was devised for the synthesis of glycerol carbonate (GC).
Book ChapterDOI
Microwave catalysis in organic synthesis
TL;DR: In this paper, the authors discuss the theoretical background, microwave mechanisms, and role of microwaves in different organic reactions and discuss the types of microwave reactors, current challenges in microwave-assisted synthesis regarding energy efficiency, and scale-up of organic transformations.
Book ChapterDOI
Recent advances in the synthesis of 4H-chromen-4-ones (2012 − 2021)
TL;DR: A comprehensive survey of the methodologies developed for the synthesis of 2,3-unsubstituted, 2- and 3-substitized and 2, 3-disubstitized 4 H -chromen-4-one derivatives can be found in this article .
References
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Journal ArticleDOI
Flavonoids as Antioxidants
TL;DR: This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants.
BookDOI
Microwaves in organic synthesis
TL;DR: In this article, the authors present an overview of the development and development of microwave-assisted organic synthesis and its application in the field of organic chemistry. But they do not discuss the specific properties of microwave reactions and their application in organic synthesis.
Journal ArticleDOI
Dietary flavonoids : Intake, health effects and bioavailability
TL;DR: It is found that human absorption of the quercetin glycosides from onions (52%) is far better than that of the pure aglycone (24%) and might contribute to the antioxidant defences of blood.
Journal ArticleDOI
Polyethylene glycol and solutions of polyethylene glycol as green reaction media
TL;DR: Aqueous biphasic reactive extraction (ABRE) can successfully integrate the solvent properties of polyethylene glycol (PEG) and its phase-transfer characteristics into a single efficient system which can additionally be manipulated to facilitate the separation of reactants and/or catalysts from products.
Journal ArticleDOI
Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
Haydee Viola,Cristina Wasowski,M Levi de Stein,C. Wolfman,Rodolfo Silveira,Federico Dajas,Jorge H. Medina,A.C. Paladini +7 more
TL;DR: It is demonstrated that apigenin is a ligand for the central benzodiazepine receptors exerting anxiolytic and slight sedative effects but not being anticonvulsant or myorelaxant.