Journal ArticleDOI
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.
Gokhan Zengin,Azzurra Stefanucci,Maria João Rodrigues,Adriano Mollica,Luísa Custódio,Muhammad Zakariyyah Aumeeruddy,Mohamad Fawzi Mahomoodally +6 more
TLDR
Investigation into the biological properties of various solvent extracts of the roots and aerial parts of Scrophularia lucida based on its antioxidant, anti‐inflammatory, and enzyme inhibitory activities revealed that the solvent extracts differed in their biological effectiveness.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2019-01-05. It has received 55 citations till now. The article focuses on the topics: Ethyl acetate & Rosmarinic acid.read more
Citations
More filters
Journal ArticleDOI
Advances on the antioxidant peptides from edible plant sources
TL;DR: This review pays particular attention to studies which successfully determined the sequences of antioxidant peptides under investigation, particularly their biological effects, mechanisms, and structure-activity relationship.
Journal ArticleDOI
Phytochemical profiling, in vitro biological properties and in silico studies on Caragana ambigua stocks (Fabaceae): A comprehensive approach
Saima Khan,Mamona Nazir,Naheed Raiz,Muhammad Saleem,Gokhan Zengin,Gazala Fazal,Hammad Saleem,Hammad Saleem,Mahreen Mukhtar,Muhammad Imran Tousif,Rasool Baksh Tareen,Hassan H. Abdallah,Hassan H. Abdallah,Fawzi M. Mahomoodally +13 more
TL;DR: In this article, the chemical and biological effects of different extracts of different Caragana ambigua stocks (Fabaceae) were determined using standard spectrophotometric methods, whereas, the secondary metabolites composition was established by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) analysis.
Journal ArticleDOI
Supercritical carbon dioxide extraction of plant phytochemicals for biological and environmental applications - A review
Thanigaivelan Arumugham,Krishnamoorthy Rambabu,Shadi W. Hasan,Pau Loke Show,Jörg Rinklebe,Jörg Rinklebe,Fawzi Banat +6 more
TL;DR: Recently, supercritical fluid CO2 extraction (SFE) has emerged as a promising and pervasive technology over conventional extraction techniques for various applications, especially for bioactive compounds extraction and environmental pollutants removal.
Journal ArticleDOI
Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey.
Gokhan Zengin,Maria João Rodrigues,Hassan H. Abdallah,Luísa Custódio,Azzurra Stefanucci,Muhammad Zakariyyah Aumeeruddy,Adriano Mollica,Kannan R.R. Rengasamy,Mohamad Fawzi Mahomoodally +8 more
TL;DR: Extracts of S. salsuginea are a potential source of functional food ingredients but need further analytical experiments to explore its complexity of chemical compounds and pharmacological properties as well as using in vivo toxicity models to establish its maximum tolerated dose.
Journal ArticleDOI
Iberian dry-cured ham as a potential source of α-glucosidase-inhibitory peptides
TL;DR: The α-glucosidase inhibitory activity of previously identified bioactive peptides in Spanish dry-cured ham such as AEEEYPDL and LGVGG was established, confirming their multifunctionality.
References
More filters
Journal ArticleDOI
Practical problems when using ABTS assay to assess the radical-scavenging activity of peptides: Importance of controlling reaction pH and time.
TL;DR: The observed biphasic kinetic pattern as well as the high TEAC values for these amino acids and peptides could be a result of combined antioxidant behaviors of themselves plus the generated reaction products.
Journal ArticleDOI
Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics.
TL;DR: It is proposed that marked ionisation of organic acids such as RA and its metabolites at physiological pH greatly limits their intracellular accumulation, and so attenuates intrinsic antioxidant ability demonstrated in the non-cellular assay.
Journal ArticleDOI
The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: Discovery of an active cardiac glycoside from Urginea maritima
Hesham R. El-Seedi,Robert Burman,Ahmed M. Mansour,Zaki Turki,Loutfy Boulos,Joachim Gullbo,Ulf Göransson +6 more
TL;DR: The value of plants used in traditional medicine as sources of medicinally interesting cytotoxic compounds is demonstrated, including those from Asclepias sinaica, Urginea maritima, Nerium oleander and Catharanthus roseus.
Journal ArticleDOI
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential
Adriano Mollica,Gokhan Zengin,Marcello Locatelli,Azzurra Stefanucci,Andrei Mocan,Andrei Mocan,Giorgia Macedonio,Simone Carradori,Olakunle J. Onaolapo,Adejoke Y. Onaolapo,Juliet Adegoke,Marufat Olaniyan,Abdurrahman Aktumsek,Ettore Novellino +13 more
TL;DR: Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection.
Journal ArticleDOI
Screening of in vitro antioxidant and enzyme inhibitory activities of different extracts from two uninvestigated wild plants: Centranthus longiflorus subsp. longiflorus and Cerinthe minor subsp. auriculata
Gokhan Zengin,Srinivasan Nithiyanantham,Marcello Locatelli,Ramazan Ceylan,Sengul Uysal,Abdurrahman Aktumsek,Palanisamy Kalai Selvi,Pavle Mašković +7 more
TL;DR: Organic extracts showed the highest anti-cholinesterase (AChE, and BChE) activity, while aqueous extracts showed valuable Tyrosinase inhibitory activity, which can represent a good model for the development of new drug formulations.