Journal ArticleDOI
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles.
Gokhan Zengin,Azzurra Stefanucci,Maria João Rodrigues,Adriano Mollica,Luísa Custódio,Muhammad Zakariyyah Aumeeruddy,Mohamad Fawzi Mahomoodally +6 more
TLDR
Investigation into the biological properties of various solvent extracts of the roots and aerial parts of Scrophularia lucida based on its antioxidant, anti‐inflammatory, and enzyme inhibitory activities revealed that the solvent extracts differed in their biological effectiveness.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2019-01-05. It has received 55 citations till now. The article focuses on the topics: Ethyl acetate & Rosmarinic acid.read more
Citations
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Journal ArticleDOI
Advances on the antioxidant peptides from edible plant sources
TL;DR: This review pays particular attention to studies which successfully determined the sequences of antioxidant peptides under investigation, particularly their biological effects, mechanisms, and structure-activity relationship.
Journal ArticleDOI
Phytochemical profiling, in vitro biological properties and in silico studies on Caragana ambigua stocks (Fabaceae): A comprehensive approach
Saima Khan,Mamona Nazir,Naheed Raiz,Muhammad Saleem,Gokhan Zengin,Gazala Fazal,Hammad Saleem,Hammad Saleem,Mahreen Mukhtar,Muhammad Imran Tousif,Rasool Baksh Tareen,Hassan H. Abdallah,Hassan H. Abdallah,Fawzi M. Mahomoodally +13 more
TL;DR: In this article, the chemical and biological effects of different extracts of different Caragana ambigua stocks (Fabaceae) were determined using standard spectrophotometric methods, whereas, the secondary metabolites composition was established by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) analysis.
Journal ArticleDOI
Supercritical carbon dioxide extraction of plant phytochemicals for biological and environmental applications - A review
Thanigaivelan Arumugham,Krishnamoorthy Rambabu,Shadi W. Hasan,Pau Loke Show,Jörg Rinklebe,Jörg Rinklebe,Fawzi Banat +6 more
TL;DR: Recently, supercritical fluid CO2 extraction (SFE) has emerged as a promising and pervasive technology over conventional extraction techniques for various applications, especially for bioactive compounds extraction and environmental pollutants removal.
Journal ArticleDOI
Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey.
Gokhan Zengin,Maria João Rodrigues,Hassan H. Abdallah,Luísa Custódio,Azzurra Stefanucci,Muhammad Zakariyyah Aumeeruddy,Adriano Mollica,Kannan R.R. Rengasamy,Mohamad Fawzi Mahomoodally +8 more
TL;DR: Extracts of S. salsuginea are a potential source of functional food ingredients but need further analytical experiments to explore its complexity of chemical compounds and pharmacological properties as well as using in vivo toxicity models to establish its maximum tolerated dose.
Journal ArticleDOI
Iberian dry-cured ham as a potential source of α-glucosidase-inhibitory peptides
TL;DR: The α-glucosidase inhibitory activity of previously identified bioactive peptides in Spanish dry-cured ham such as AEEEYPDL and LGVGG was established, confirming their multifunctionality.
References
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Phenolic profiles, antioxidant capacities and metal chelating ability of edible mushrooms commonly consumed in China
TL;DR: In this article, the authors evaluated the antioxidant properties of 43 commonly consumed mushrooms in China using ABTS free radical scavenging (ABTS) assay, DPPH free-radical scavenging and ferric reducing antioxidant power (FRAP) assays, and metal chelating ability (MCA) assay.
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An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco.
TL;DR: Local medicinal plant knowledge is rich in the High Atlas, where local populations still rely on medicinal plants for healthcare, and experimental evidence of safe and effective use of medicinal plants is found, but the use of eight poisonous species is highlighted.
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Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae.
TL;DR: The amino acid sequence comparisons with α-glucosidases showed that a bulky hydrophobic amino acid residue is conserved at the position of Val216 in α-1,6-glUCosidic linkage hydrolyzing enzymes, which may be largely responsible for determining the substrate specificity of α- Gln279, and two isomaltase mutant enzymes - V216T and Q279A - hydrolyzed maltose.
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Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations
Gokhan Zengin,Ahmet Uysal,Abdurrahman Aktumsek,Andrei Mocan,Adriano Mollica,Marcello Locatelli,Luísa Custódio,Nuno R. Neng,José M.F. Nogueira,Zaahira Aumeeruddy-Elalfi,M. Fawzi Mahomoodally +10 more
TL;DR: In this study, Methanolic extracts of Euphorbia denticulata parts were assessed for a panoply of bioactivities and can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals.
Journal ArticleDOI
Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis.
TL;DR: Assessment of protein expression levels by western blot analysis revealed that luteolin treatment effectively negates B(a)P-induced upregulated expression of proliferating cell nuclear antigen (PCNA), cytochrome P450 1A1 (CYP1A1) and nuclear factor-kappa B (NF-κB).