Journal ArticleDOI
Selective demethylation of 3,4-dimethoxy-substituted aromatic aldehydes and ketones
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This article is published in Journal of Organic Chemistry.The article was published on 1967-04-01. It has received 19 citations till now. The article focuses on the topics: Demethylation.read more
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Development of a Pilot Scale Process for the Anti-Alzheimer Drug (−)-Galanthamine Using Large-Scale Phenolic Oxidative Coupling and Crystallisation-Induced Chiral Conversion
TL;DR: (−)-Galanthamine has been synthesised using an efficient nine-step procedure, which in large scale affords 12.4 (6.7−19.1)% overall yield.
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A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent
Yali Kong,Kan Wang,Michael C. Edler,Ernest Hamel,Susan L. Mooberry,Mikell Paige,Milton L. Brown +6 more
TL;DR: This study identified a boronic acid chalcone with inhibition towards 16 human cancer cell lines in the 10-200nM range, and another three cell lines with GI(50)-values below 10nM, which has significant anti-angiogenesis effects demonstrated by HUVEC tube formation and aortic ring assay.
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Isolation and structure of two new dihydroisocoumarins from Kigelia pinnata
TL;DR: Two dihydroisocoumarins (IIIa and IVa) have been isolated from Kigelia pinnata and their structures established as mentioned in this paper, and Stigmasterol, β-sitosterol, lapachol and 6-methoxymellein were also identified in the roots and bark.
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High Selectivity in the Oxidation of Mandelic Acid Derivatives and in O-Methylation of Protocatechualdehyde: New Processes for Synthesis of Vanillin, iso-Vanillin, and Heliotropin
Lucia Liguori,Francesco Minisci +1 more
TL;DR: In this article, new synthetic procedures for vanillin, iso-vanillin, heliotropin, and protocatechualdehyde starting from catechol are described.
Journal ArticleDOI
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.
Tracey Pirali,Sara Busacca,Lorena Beltrami,Daniela Imovilli,Francesca Pagliai,Gianluca Miglio,Alberto Massarotti,Luisella Verotta,Gian Cesare Tron,Giovanni Sorba,Armando A. Genazzani +10 more
TL;DR: R rigid analogues of combretastatin bearing a furan ring in place of the olefinic bridge are synthesized and it is possible that combretafurans could act as scaffolds for the development of dual-action antitumoral agents.