J
Jennifer K. Lodge
Researcher at Washington University in St. Louis
Publications - 83
Citations - 5430
Jennifer K. Lodge is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cryptococcus neoformans & Virulence. The author has an hindex of 40, co-authored 79 publications receiving 4937 citations. Previous affiliations of Jennifer K. Lodge include Saint Louis University & University of Washington.
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Journal ArticleDOI
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus Neoformans
Brendan J. Loftus,Eula Fung,Paola Roncaglia,Don Rowley,Paolo Amedeo,Dan Bruno,Jessica Vamathevan,Molly Miranda,Iain J. Anderson,James A. Fraser,Jonathan E. Allen,Ian Bosdet,Michael R. Brent,Readman Chiu,Tamara L. Doering,Maureen J. Donlin,Cletus D'Souza,Deborah S. Fox,Deborah S. Fox,Viktoriya Grinberg,Jianmin Fu,Marilyn Fukushima,Brian J. Haas,James Huang,Guilhem Janbon,Steven J.M. Jones,Hean L. Koo,Martin Krzywinski,June Kwon-Chung,Klaus B. Lengeler,Klaus B. Lengeler,Rama Maiti,Marco A. Marra,Robert E. Marra,Robert E. Marra,Carrie Mathewson,Thomas G. Mitchell,Mihaela Pertea,Florenta R. Riggs,Steven L. Salzberg,Jacqueline E. Schein,Alla Shvartsbeyn,Heesun Shin,Martin Shumway,Charles A. Specht,Bernard B. Suh,Aaron Tenney,T. Utterback,Brian L. Wickes,Jennifer R. Wortman,Natasja Wye,James W. Kronstad,Jennifer K. Lodge,Joseph Heitman,Ronald W. Davis,Claire M. Fraser,Richard W. Hyman +56 more
TL;DR: Comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes, and the genome is rich in transposons, many of which cluster at candidate centromeric regions.
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Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
Guilhem Janbon,Kate L. Ormerod,Damien Paulet,Edmond J. Byrnes,Vikas Yadav,Gautam Chatterjee,Nandita Mullapudi,Chung-Chau Hon,R. Blake Billmyre,François Brunel,Yong Sun Bahn,Weidong Chen,Yuan Chen,Eve W. L. Chow,Jean Yves Coppée,Anna Floyd-Averette,Claude Gaillardin,Kimberly J. Gerik,Jonathan M. Goldberg,Sara Gonzalez-Hilarion,Sharvari Gujja,Joyce L. Hamlin,Yen-Ping Hsueh,Yen-Ping Hsueh,Giuseppe Ianiri,Steven J.M. Jones,Chinnappa D. Kodira,Lukasz Kozubowski,Woei Lam,Marco A. Marra,Larry D. Mesner,Piotr A. Mieczkowski,Frédérique Moyrand,Kirsten Nielsen,Kirsten Nielsen,Caroline Proux,Tristan Rossignol,Jacqueline E. Schein,Sheng Sun,Carolin Wollschlaeger,Ian A. Wood,Qiandong Zeng,Cécile Neuvéglise,Carol S. Newlon,John R. Perfect,Jennifer K. Lodge,Alexander Idnurm,Jason E. Stajich,Jason E. Stajich,James W. Kronstad,Kaustuv Sanyal,Joseph Heitman,James A. Fraser,Christina A. Cuomo,Fred S. Dietrich +54 more
TL;DR: The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.
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Chitosan, the Deacetylated Form of Chitin, Is Necessary for Cell Wall Integrity in Cryptococcus neoformans
TL;DR: Utilizing a collection of chitin/polysaccharide deacetylase deletion strains, it is determined that during vegetative growth, chitosan helps to maintain cell integrity and aids in bud separation.
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Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein
TL;DR: Exogenous application of pokeweed antiviral protein (PAP), a ribosome-inhibiting protein found in the cell walls of Phytolacca americana (pokeweed), protects heterologous plants from viral infection.
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A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans.
Isaac R. Banks,Charles A. Specht,Maureen J. Donlin,Kimberly J. Gerik,Stuart M. Levitz,Jennifer K. Lodge +5 more
TL;DR: It is shown that both chitin and chitosan are present in the cell wall of vegetatively growing C. neoformans yeast cells and that the levels of both rise dramatically as cells grow to higher density in liquid culture, suggesting that chit in synthesis could be an excellent antifungal target.