Journal ArticleDOI
Separation of the cyclization and rearrangement processes of lanosterol biosynthesis. Enzymic conversion of 20,21-dehydro-2,3-oxidosqualene to a dehydroprotosterol.
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This article is published in Journal of the American Chemical Society.The article was published on 1969-04-09. It has received 20 citations till now. The article focuses on the topics: 2,3-Oxidosqualene & Lanosterol.read more
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New reaction and new catalyst—a personal perspective
TL;DR: A number of new synthetic methods are reviewed in this article, most of which are based on aluminum, boron, tin, silver Lewis acids and/or Bronsted acid catalysts.
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Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase.
TL;DR: A series of mono- and bifunctional squalenoid acetylenes and allenes were synthesized and some of them proved to be inhibitors of squalene epoxidase, and new "suicide" inhibitors of SO cyclase were attempted, such as a squAlenoid epoxide vinyl ether.
Journal ArticleDOI
Synthesis of (+)-Coronafacic Acid
TL;DR: An enantioselective synthesis of (+)-coronafacic acid has been achieved by Rhodium-catalyzed cyclization of an alpha-diazoester that gave a bicyclic enone that was hydrogenated and carried on to the natural product.