Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay.
TLDR
Serological antibody-absorption tests indicated that the patients in two cases were infected by R. parkeri, the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis.Abstract:
We report three new rickettsiosis human cases in Uruguay. The three clinical cases presented clinical manifestations similar to previous reported cases of Rickettsia parkeri in the United States; that is mild fever (< 40 oC), malaise, headache, rash, inoculation eschar at the tick bite site, regional lymphadenopathy, and no lethality. Serological antibody-absorption tests with purified antigens of R. parkeri and Rickettsia rickettsii, associated with immunofluorescence assay indicated that the patients in two cases were infected by R. parkeri. Epidemiological and clinical evidences, coupled with our serological analysis, suggest that R. parkeri is the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis.read more
Citations
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Update on Tick-Borne Rickettsioses around the World: a Geographic Approach
Philippe Parola,Christopher D. Paddock,Cristina Socolovschi,Marcelo Bahia Labruna,Oleg Mediannikov,Tahar Kernif,Mohammad Yazid Abdad,John Stenos,Idir Bitam,Pierre-Edouard Fournier,Didier Raoult +10 more
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TL;DR: The CDC Rickettsial Zoonoses Branch developed this report to assist health care providers and public health professionals to recognize key epidemiologic features and clinical manifestations of tickborne rickettsial diseases, and understand that early empiric antibacterial therapy can prevent severe disease and death.
Journal ArticleDOI
Rickettsioses in Latin America, Caribbean, Spain and Portugal
Marcelo Bahia Labruna,Salim Mattar,Santiago Nava,Sergio E. Bermúdez,José M. Venzal,Gaby Dolz,Katia Abarca,Luis Romero,Rita de Sousa,José A. Oteo,Jorge Zavala-Castro +10 more
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In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil.
M. P. J. Szabó,Fernanda A. Nieri-Bastos,Mariana Granziera Spolidorio,Thiago F. Martins,Amália Regina Mar Barbieri,Marcelo Bahia Labruna +5 more
TL;DR: It is concluded that AtlanticRainforest genotype circulates in this Atlantic rainforest area at relatively high levels, and dogs get infected when bitten by A. ovale ticks in the forest, and carry infected ticks to households.
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The Evolving Medical and Veterinary Importance of the Gulf Coast tick (Acari: Ixodidae).
TL;DR: Renewed interest in the Gulf Coast tick reinforces the notion that the perceived importance of a particular tick species to human or animal health can be relatively fluid, and may shift dramatically with changes in the distribution and abundance of the arthropod, its vertebrate hosts, or the microbial agents that transit among these organisms.
References
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Journal ArticleDOI
Rickettsia parkeri: A newly recognized cause of spotted fever rickettsiosis in the United States
Christopher D. Paddock,John W. Sumner,James A. Comer,Sherif R. Zaki,Cynthia S. Goldsmith,Jerome Goddard,Susan McLellan,Cynthia L. Tamminga,Christopher A. Ohl,Christopher A. Ohl +9 more
TL;DR: Disease in a human caused by Rickettsia parkeri is described, an SFG rickettsia first identified >60 years ago in Gulf Coast ticks collected from the southern United States, and application of specific laboratory assays to clinical specimens obtained from patients with febrile, eschar-associated illnesses following a tick bite may identify additional cases.
Journal Article
Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals.
Alice S. Chapman,Johan S. Bakken,Scott M. Folk,Christopher D. Paddock,Karen C. Bloch,Allan Krusell,Daniel J. Sexton,Steven C. Buckingham,Gary S. Marshall,Gregory Storch,Gregory A. Dasch,Jennifer H. McQuiston,David L. Swerdlow,Stephen J. Dumler,William L. Nicholson,David H. Walker,Marina E. Eremeeva,Christopher A. Ohl +17 more
TL;DR: This report will assist clinicians and other health-care and public health professionals to develop a differential diagnosis that includes and ranks TBRD, understand that the recommendations for doxycycline are the treatment of choice for both adults and children, and understand that early empiric antibiotic therapy can prevent severe morbidity and death.
Journal ArticleDOI
Rickettsia parkeri Rickettsiosis and Its Clinical Distinction from Rocky Mountain Spotted Fever
Christopher D. Paddock,Richard W. Finley,Cynthia S. Wright,Howard N. Robinson,Barbara J. Schrodt,Carole C. Lane,Okechukwu Ekenna,Mitchell A. Blass,Cynthia L. Tamminga,Christopher A. Ohl,Susan McLellan,Jerome Goddard,Robert C. Holman,John J. Openshaw,John W. Sumner,Sherif R. Zaki,Marina E. Eremeeva +16 more
TL;DR: Closer attention to the distinct clinical features of the various spotted fever syndromes that exist in the United States and other countries of the Western hemisphere may unveil several unique diseases that have been identified collectively as Rocky Mountain spotted fever during the past century.
Journal ArticleDOI
Rickettsia infection in five areas of the state of São Paulo, Brazil
Mauricio Claudio Horta,Marcelo Bahia Labruna,Adriano Pinter,Pedro Marcos Linardi,Teresinha Tizu Sato Schumaker +4 more
TL;DR: Serological results suggest that both R. rickettsii and R. parkeri infected animals and/or humans in the studied areas.
Journal ArticleDOI
Prevalence of Rickettsia infection in dogs from the urban and rural areas of Monte Negro municipality, western Amazon, Brazil.
Marcelo Bahia Labruna,Mauricio Claudio Horta,Daniel Moura de Aguiar,Guacyara Tenório Cavalcante,Adriano Pinter,Solange Maria Gennari,Luís Marcelo Aranha Camargo +6 more
Abstract: The present study evaluated the rickettsial infection among dogs living in the rural and urban areas of Monte Negro, state of Rondonia, western Brazilian Amazon. Canine sera were tested by the indirect immunofluorescence assay (IFA) using six rickettsial antigens: Rickettsia bellii, Rickettsia amblyommii, Rickettsia rhipicephali, Rickettsia rickettsii, Rickettsia parkeri, and Rickettsia felis. While the first three Rickettsia species are known to occur in the study site, the latter three species are known to occur in southeastern Brazil. For each serum, end point titer reacting with each Rickettsia antigen was determined. Serum showing for a Rickettsia species titer at least fourfold higher than that observed for any other Ricketttsia species was considered homologous to the first Rickettsia species or to a very closely related genotype. A total of 164 rural and 153 urban dogs were tested. Overall, 19 (11.6%) and 6 (3.9%) dogs from rural and urban areas, respectively, reacted positively to at least one Rickettsia species. In the rural area, three sera showed titers to R. parkeri at least four-fold higher than any of the other five antigens. These sera were considered to be homologous to R. parkeri or a very closely related genotype. Using the same criteria, two rural sera were considered homologous to R. amblyommii, two other rural sera to R. rhipicephali, and one urban serum to R. parkeri. Because dogs living in the rural area of Monte Negro are commonly infested by the same tick species infesting humans, they indeed serve as sentinels for human rickettsial diseases. Thus, humans living in Monte Negro are likely to be infected by at least three Rickettsia species: R. parkeri, R. amblyommii, and R. rhipicephali. While R. parkeri is a known human pathogen, further studies are required to verify the potential role of R. amblyommii and R. rhipicephali as human pathogens.
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