Journal ArticleDOI
Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in non-diabetic patients with stage 2-4 chronic kidney disease.
Jolanta Malyszko,Hanna Bachórzewska-Gajewska,E. Sitniewska,Jacek S. Malyszko,Bogusław Poniatowski,Sławomir Dobrzycki +5 more
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TLDR
NGAL should be investigated as a potential early and sensitive marker of kidney impairment/injury in adult patients with CKD, taking into consideration the fact that individuals with reduced GRF are at greater risk for CVD and cardiac deaths.Abstract:
The current Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines advocate creatinine-based equations for estimating GFR to identify patients with potential kidney disease and classify them into different stages due to the fact that serum creatinine is very insensitive to changes in the glomerular filtration rate. Very few biomarkers exist for monitoring chronic kidney disease. The aim of the study was to assess whether NGAL could represent a novel, sensitive marker of kidney function in adult patients with CKD. The study was performed on 92 non-diabetic patients with CKD stages 2-4. Serum and urinary NGAL as well as serum cystatin C were measured using commercially available kits. Serum NGAL was related, in univariate analysis, to serum creatinine, urinary NGAL, hemoglobin, hematocrit, leukocyte count, eGFR, and cystatin C. Urinary NGAL correlated with age, hemoglobin, hematocrit, serum creatinine, and eGFR. In multiple regression analysis, predictors of serum NGAL were creatinine (beta value = 0.97, p = 0.005), cystatin C (beta = 0.34, p = 0.01), and eGFR (beta value = 1.77, p = 0.001). In the healthy volunteers, serum NGAL correlated with age, serum creatinine, eGFR, leukocyte count, and cystatin C. Taking into consideration the fact that the recent DOQI (Dialysis Outcomes Quality Initiative) states that individuals with reduced GRF (glomerular filtration rate) are at greater risk for CVD and cardiac deaths, precise evaluation of renal function is important in order to select the appropriate strategy to reduce the cardiovascular risk. NGAL should be investigated as a potential early and sensitive marker of kidney impairment/injury.read more
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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
TL;DR: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular reactive oxygen species (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive as discussed by the authors.
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Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
TL;DR: It is argued that the role of poorly liganded iron has been rather underappreciated in the past, and that in combination with peroxide and superoxide its activity underpins the behaviour of a great many physiological processes that degrade over time.
Journal ArticleDOI
Biomarkers in chronic kidney disease: a review
Robert G. Fassett,Robert G. Fassett,S. K. Venuthurupalli,S. K. Venuthurupalli,Glenda C. Gobe,Jeff S. Coombes,Mark E. Cooper,Wendy E. Hoy +7 more
TL;DR: It is timely to review the role of promising biomarkers in predicting CKD progression and/or CVD risk in CKD, including neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and liver-type fatty acid-binding protein.
Journal ArticleDOI
Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury.
TL;DR: The discovery, translation and validation of neutrophil gelatinase‐associated lipocalin (NGAL), possibly the most promising novel AKI biomarker, is reviewed and is emerging as an excellent stand‐alone troponin‐like structural biomarker in the plasma and urine for the early diagnosis of AKI.
Journal ArticleDOI
Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury
TL;DR: The discovery, translation and validation of neutrophil gelatinase-associated lipocalin, arguably the most promising novel AKI biomarker, are reviewed and emerging as an excellent standalone troponin-like biomarker in the plasma and urine for the prediction of AKI.
References
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Journal Article
K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification
Andrew S. Levey,Josef Coresh,Kline Bolton,Bruce Culleton,Kathy Schiro Harvey,T. Alp Ikizler,Cynda Ann Johnson,Annamaria T. Kausz,Paul L. Kimmel,John W. Kusek,Adeera Levin,Kenneth L. Minaker,Robert Nelson,Helmut G. Rennke,Michael Steffes,Beth Witten,Ronald J. Hogg,Susan Furth,Kevin V. Lemley,Ronald J. Portman,George Schwartz,Joseph Lau,Ethan M Balk,Ronald D. Perrone,Tauqeer Karim,Lara Rayan,Inas Al-Massry,Priscilla Chew,Brad C. Astor,Deirdre De Vine,Garabed Eknoyan,Nathan W. Levin,Sally Burrows-Hudson,William F. Keane,Alan S. Kliger,Derrick Latos,Donna Mapes,Edith Oberley,Kerry Willis,George R. Bailie,Gavin J. Becker,Jerrilynn Burrowes,David Churchill,Allan J. Collins,William Couser,Dick DeZeeuw,Alan Garber,Thomas Golper,Frank A. Gotch,Antonio M. Gotto,Joel W. Greer,Richard H. Grimm,Ramon G. Hannah,Jaime Herrera Acosta,Ronald J. Hogg,Lawrence G. Hunsicker,Michael J. Klag,Saulo Klahr,Caya Lewis,Edmund G. Lowrie,Arthur J. Matas,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith Norris,William F. Owen,Thakor G. Patel,Glenda Payne,Rosa A. Rivera-Mizzoni,David A. Smith,Robert A. Star,Theodore Steinman,Fernando Valderrábano,John Walls,Jean Pierre Wauters,Nanette Wenger,Josephine P. Briggs +78 more
TL;DR: In the early 1990s, the National Kidney Foundation (K/DOQI) developed a set of clinical practice guidelines to define chronic kidney disease and to classify stages in the progression of kidney disease.
Journal ArticleDOI
Asymmetrical Dimethylarginine Predicts Progression to Dialysis and Death in Patients with Chronic Kidney Disease: A Competing Risks Modeling Approach
Pietro Ravani,Giovanni Tripepi,Fabio Malberti,Sophie Testa,Francesca Mallamaci,Carmine Zoccali +5 more
TL;DR: In patients with mild to advanced chronic kidney disease, plasma ADMA is inversely related to GFR and represents a strong and independent risk marker for progression to ESRD and mortality.
Journal ArticleDOI
Biomarkers of inflammation and progression of chronickidney disease
TL;DR: Pravastatin appears to prevent loss of kidney function to a greater extent in individuals with greater evidence of inflammation, although this was of borderline significance, and data suggest that inflammation may mediate the loss of kidneys function among subjects with chronic kidney disease and concomitant coronary disease.
Journal ArticleDOI
Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease.
Mark Mitsnefes,Thelma Kathman,Jaya Mishra,Janis Kartal,Philip R. Khoury,Thomas L. Nickolas,Jonathan Barasch,Prasad Devarajan +7 more
TL;DR: It is concluded that both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and by correlation analysis, NGAL outperforms cyStatin C and eGFR at lower levels of measured GFR.
Journal ArticleDOI
Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia.
Kai M. Schmidt-Ott,Kiyoshi Mori,Avtandil Kalandadze,Jau Yi Li,Neal Paragas,Thomas Nicholas,Prasad Devarajan,Jonathan Barasch +7 more
TL;DR: NGAL is rapidly and massively induced in renal epithelial injury and NGAL: siderophore: iron complexes may comprise a physiological renoprotective mechanism, which has implications for the diagnosis and treatment of acute renal injury.
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Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
Kiyoshi Mori,H. Thomas Lee,Dana Rapoport,Ian R. Drexler,Kirk W. Foster,Jun Yang,Kai M. Schmidt-Ott,Xia Chen,Jau Yi Li,Stacey F. Weiss,Jaya Mishra,Faisal H. Cheema,Glenn Markowitz,Takayoshi Suganami,Kazutomo Sawai,Masashi Mukoyama,Cheryl L. Kunis,Vivette D. D'Agati,Prasad Devarajan,Jonathan Barasch +19 more