Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children
Richard Idro,Angelina Kakooza-Mwesige,Stephen Balyejjussa,Grace Mirembe,Christine Mugasha,Joshua Tugumisirize,Justus Byarugaba +6 more
TLDR
Describing functional deficits and behaviour problems in children who survived cerebral malaria with severe neurological sequelae and identifying patterns of brain injury found Cerebral malaria may be used as a new model to study the pathogenesis of ADHD.Abstract:
Background
Cerebral malaria is the most severe neurological complication of falciparum malaria and a leading cause of death and neuro-disability in sub-Saharan Africa. This study aimed to describe functional deficits and behaviour problems in children who survived cerebral malaria with severe neurological sequelae and identify patterns of brain injury.read more
Citations
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Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study
Gretchen L. Birbeck,Malcolm E. Molyneux,Peter W. Kaplan,Karl B. Seydel,Karl B. Seydel,Yamikani Chimalizeni,Kondwani Kawaza,Terrie E. Taylor,Terrie E. Taylor +8 more
TL;DR: Almost a third of retinopathy-positive cerebral malaria survivors developed epilepsy or other neurobehavioural sequelae, and neuroprotective clinical trials aimed at managing hyperpyrexia and optimising seizure control are warranted.
Journal ArticleDOI
The roles of TNF in brain dysfunction and disease.
TL;DR: This review summarizes the burgeoning literature on cytokines, and how the functions of these molecules, particularly TNF, are influencing the outlook of researchers on the pathophysiology of these diseases, including Alzheimer's disease and other encephalopathies.
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Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
TL;DR: These variant surface antigens are suggested to mediate the sequestration of infected erythrocytes in the microvasculature and block the blood flow when binding is excessive.
Journal ArticleDOI
The 'Hidden' Burden of Malaria: Cognitive Impairment Following Infection
TL;DR: Cognitive abilities and school performance were shown to be impaired in sub-groups of patients (with either cerebral malaria or uncomplicated malaria) when compared with healthy controls and Malaria prophylaxis was shown to improve cognitive function andSchool performance in clinical trials when compared to placebo groups.
Journal ArticleDOI
Social implications of malaria and their relationships with poverty
TL;DR: The various aspects that make malaria a disease closely related to poverty and the effects of malaria on the same poverty of patients who are affected are discussed in this article.
References
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Development and reliability of a system to classify gross motor function in children with cerebral palsy
Robert J. Palisano,Peter Rosenbaum,Stephen D. Walter,Dianne J Russell,Ellen Wood,Barbara Galuppi +5 more
TL;DR: A five‐level classification system analogous to the staging and grading systems used in medicine, which has application for clinical practice, research, teaching, and administration is developed.
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Severe falciparum malaria.
TL;DR: Children having pulmonary edema, shock and cerebral malaria had high case fatality rate and over all mortality was 9.9%, cerebral malaria being the commonest cause and multi-system involvement was seen in 58.4% cases of death.
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Clinical Features and Prognostic Indicators in Paediatric Cerebral Malaria: A Study of 131 Comatose Malawian Children
TL;DR: A prognostic index based on eight risk factors that can readily be ascertained at the bedside or in a ward sideroom, was more accurately predictive of outcome than any single feature.
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Differentiating the pathologies of cerebral malaria by postmortem parasite counts.
Terrie E. Taylor,Wenjiang J. Fu,Wenjiang J. Fu,Richard A. Carr,Richard O. Whitten,Jeffrey G Mueller,Nedson G Fosiko,Susan Lewallen,N George Liomba,Malcolm E. Molyneux,Malcolm E. Molyneux +10 more
TL;DR: Autopsies in 31 children diagnosed with fatal cerebral malaria found that 23% of the children had actually died from other causes, and retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma.