Journal ArticleDOI
Sheathless elasto-inertial particle focusing and continuous separation in a straight rectangular microchannel
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TLDR
A novel method for sheathless particle focusing, called "Elasto-Inertial Particle Focusing", was demonstrated in a straight microchannel and it is expected that this method can contribute to develop the miniaturized flow cytometry and microdevices for cell and particle manipulation.Abstract:
Particle focusing in planar geometries is essentially required in order to develop cost-effective lab-on-a-chips, such as cell counting and point-of-care (POC) devices. In this study, a novel method for sheathless particle focusing, called “Elasto-Inertial Particle Focusing”, was demonstrated in a straight microchannel. The particles were notably aligned along the centerline of the straight channel under a pressure-driven flow without any additional external force or apparatus after the addition of an elasticity enhancer: PEO (poly(ethylene oxide)) (∼O(100) ppm). As theoretically predicted (elasticity number: El ≈ O(100)), multiple equilibrium positions (centerline and corners) were observed for the viscoelastic flow without inertia, whereas three-dimensional particle focusing only occurred when neither the elasticity nor the inertia was negligible. Therefore, the three-dimensional particle focusing mechanism was attributed to the synergetic combination of the elasticity and the inertia (elasticity number: El ≈ O(1–10)). Furthermore, from the size dependence of the elastic force upon particles, we demonstrated that a mixture of 5.9 and 2.4 µm particles was separated at the exit of the channel in viscoelastic flows. We expect that this method can contribute to develop the miniaturized flow cytometry and microdevices for cell and particle manipulation.read more
Citations
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Journal ArticleDOI
Inertial microfluidic physics
TL;DR: It is hoped that an improved fundamental and quantitative understanding of inertial fluid dynamic effects can lead to unprecedented capabilities to program fluid and particle flow towards automation of biomedicine, materials synthesis, and chemical process control.
Journal ArticleDOI
Inertial Focusing in Microfluidics
Joseph M. Martel,Mehmet Toner +1 more
TL;DR: The theoretical developments that have made the field of inertial focusing what it is today are described and the key applications that will make inertialocusing a mainstream technology in the future are presented.
Journal ArticleDOI
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
TL;DR: An overview of the cell/particle sorting techniques by harnessing intrinsic hydrodynamic effects in microchannels with emphasis on the underlying fluid dynamical mechanisms causing cross stream migration of objects in shear and vortical flows is presented.
Journal ArticleDOI
Particle manipulations in non-Newtonian microfluidics: A review.
TL;DR: An overview of the various passive manipulations, including focusing, separation, washing and stretching, of particles that have thus far been demonstrated in non-Newtonian microfluidics.
Journal ArticleDOI
Single line particle focusing induced by viscoelasticity of the suspending liquid: theory, experiments and simulations to design a micropipe flow-focuser
Gaetano D'Avino,Giovanni Romeo,Massimiliano M. Villone,Francesco Greco,Paolo A. Netti,Paolo A. Netti,Pier Luca Maffettone +6 more
TL;DR: This work performs 3D numerical simulations, heuristic modeling and microfluidic experiments to demonstrate, for the first time, the presence of a bistability scenario for transversal migration of particles suspended in a viscoelastic liquid flowing in a pipe.
References
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Journal ArticleDOI
Continuous inertial focusing, ordering, and separation of particles in microchannels
TL;DR: The ability to differentially order particles of different sizes, continuously, at high rates, and without external forces in microchannels is expected to have a broad range of applications in continuous bioparticle separation, high-throughput cytometry, and large-scale filtration systems.
Journal ArticleDOI
Radial Particle Displacements in Poiseuille Flow of Suspensions
G. Segré,A. Silberberg +1 more
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Multifunctional encoded particles for high-throughput biomolecule analysis.
TL;DR: This work presents a method based on continuous-flow lithography that combines particle synthesis and encoding and probe incorporation into a single process to generate multifunctional particles bearing over a million unique codes that can be scanned rapidly in a flow-through microfluidic channel.
Journal ArticleDOI
The inertial lift on a spherical particle in a plane Poiseuille flow at large channel Reynolds number
TL;DR: In this paper, the inertial migration of a small rigid sphere translating parallel to the walls within a channel flow at large channel Reynolds numbers is investigated, and the method of matched asymptotic expansions is used to solve the equations governing the disturbance flow past a particle at small particle Reynolds number and to evaluate the lift.