Should we cross off the crossover
TLDR
The simple two-treatment, two-period crossover trial provides an efficient way of comparing the efficacies of two treatments for the short-term alleviation of a chronic condition.Abstract:
The simple two-treatment, two-period crossover trial is under attack again. In ideal circumstances this design provides an efficient way of comparing the efficacies of two treatments for the short-term alleviation of a chronic conditionread more
Citations
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Journal ArticleDOI
Vitamin E for neuroleptic-induced tardive dyskinesia.
TL;DR: Small trials with uncertain quality of randomisation, tend to suggest that vitamin E improves the symptoms of TD and methodological problems such as small sample size, short term interventions, and inappropriate use of crossover design need to be dealt with.
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Feasibility Study of N-of-1 Trials With Blood Pressure Self-Monitoring in Hypertension
TL;DR: Assessing individual responses to antihypertensive treatment by N-of-1 trials using blood pressure self-monitoring in 79 patients of both sexes referred to a hypertension clinic showed no significant blood pressure regression toward the mean over 20 days and justified the choice of 5-day treatment periods in study 2.
Journal ArticleDOI
Anticholinergics for neuroleptic-induced acute akathisia.
TL;DR: There is no reliable evidence to support or refute the use of anticholinergic drugs for people suffering from neuroleptic-induced acute akathisia, and the need for well designed, conducted and reported clinical trials to address the claims of open studies is highlighted.
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Benzodiazepines for neuroleptic‐induced acute akathisia
TL;DR: Over a short follow-up period, the use of benzodiazepines may reduce the symptoms of antipsychotic-induced acute akathisia and highlights the need for well designed, conducted and reported clinical trials to address the claims of open studies.
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Systematic overview of Cochrane reviews for anticholinergic effects of antipsychotic drugs.
Mehmet Ozbilen,Clive E Adams +1 more
TL;DR: Anticholinergic symptoms are common adverse effects associated with the use of all antipsychotic drugs, and newer-generation drugs are not clearly distinguishable from many older compounds.
References
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Journal ArticleDOI
The two-period change-over design an its use in clinical trials.
TL;DR: This comparison shows that the two-period changeover design is preferable when the residual effects of the treatments are equal and the correlation between the response to the two tieatments is positive, otherwise the design in which there is random assignment to a single treatment is preferable.
Journal ArticleDOI
The performance of the two‐stage analysis of two‐treatment, two‐period crossover trials
TL;DR: It is concluded that the two-stage analysis for analysing the data from a two-treatment, two-period crossover trial is too potentially misleading to be of practical use.