Journal ArticleDOI
Significance of multifocality in papillary thyroid carcinoma.
TLDR
Only multifocality was found to be the predictor of recurrence in all PTC, PTMC, and non-PTMC patients, and an increase in the number of tumors was associated with an increased risk of ETE, vascular invasion, CLNM and LLNM.Abstract:
Background Although multifocality is often observed in papillary thyroid carcinoma (PTC), the associations with clinicopathologic factors and the prognostic value are still controversial. We aimed to identify the risk factors for multifocality and bilaterality, and investigate the significance of multifocality on prognosis in all PTC, papillary thyroid microcarcinoma (PTMC) and non-PTMC. Methods: Data from 635 patients who underwent lobectomy/total thyroidectomy plus cervical lymph node dissection for PTC were retrospectively analyzed. Clinicopathological factors associated with multifocal PTC and bilateral PTC were investigated by univariate analysis. Multivariate Cox regression analyses was used to identify the clinicopathological prognostic factors for recurrence-free survival. Results: Multifocal and bilateral PTC were observed in 157 (24.7%) and 99 (15.6%) patients, respectively. The frequency of large diameter (>1.0 cm), extrathyroidal extension (ETE), vascular invasion and central lymph node metastases (CLNM) was higher in multifocal PTC than that of solitary PTC. Moreover, ETE, vascular invasion, CLNM and lateral lymph node metastasis (LLNM) were more frequent in patients with 3 or more tumor foci compared to those with 2 tumor foci and 1 tumor lesion. Bilateral PTC had higher rates of ETE and CLNM. Multifocality was found to be the predictor of recurrence in all PTC, PTMC, and non-PTMC. In addition, the risk of recurrence increased with increasing number of tumor foci in all multifocal PTC patients and multifocal non-PTMC patients. Conclusion: Although multifocality and bilaterality had more aggressive features in PTC, only multifocality was associated with the increased risk of recurrence. An increase in the number of tumors was associated with an increased risk of ETE, vascular invasion, CLNM and LLNM. The prognostic value of multifocality is particularly significant in non-PTMC patients.read more
Citations
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Journal ArticleDOI
Association of Multifocality With Prognosis of Papillary Thyroid Carcinoma: A Systematic Review and Meta-analysis.
TL;DR: In this paper, a systematic review with meta-analysis found that multifocality was significantly associated with an increased risk of recurrence in patients with PTC, while cancer-specific survival showed no difference.
Journal ArticleDOI
Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma.
TL;DR: In this paper, the authors evaluated whether multifocality can predict the recurrence of thyroid cancer and found that multifocality increased the risk of recurrence in patients with PTC.
Journal ArticleDOI
Clinical outcomes of radiofrequency ablation for multifocal papillary thyroid microcarcinoma versus unifocal papillary thyroid microcarcinoma: a propensity-matched cohort study
TL;DR: In this paper, the clinical outcomes of radiofrequency ablation (RFA) for multifocal papillary thyroid microcarcinoma (PTMC) versus unifocal PTMC were investigated and compared between the two groups.
Journal ArticleDOI
Risk Factors for Contralateral Occult Carcinoma in Patients With Unilateral Papillary Thyroid Carcinoma: A Retrospective Study and Meta-Analysis.
TL;DR: In this article, the authors explore the frequency and investigate the risk factors of contralateral occult PTC in unilateral PTC through a retrospective study conducted by their team and published articles online, respectively.
Journal ArticleDOI
Risk Factors and Prediction Model for Lateral Lymph Node Metastasis of Papillary Thyroid Carcinoma in Children and Adolescents.
Weili Liang,Lei Sheng,Liguang Zhou,Changyuan Ding,Zhongyang Yao,Chao Gao,Qingdong Zeng,Bo Chen +7 more
TL;DR: In this paper, the authors focused on identifying risk factors and establishing prediction models for lateral lymph node metastasis (LNM) of PTC in children and adolescents, which is a high risk factor for recurrence.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013.
TL;DR: Among patients in the United States diagnosed with thyroid cancer from 1974-2013, the overall incidence of thyroid cancer increased 3% annually, with increases in the incidence rate and thyroid cancer mortality rate for advanced-stage papillary thyroid cancer.
Journal ArticleDOI
Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system.
R. Michael Tuttle,Hernán Tala,Jatin P. Shah,Rebecca Leboeuf,Ronald Ghossein,Mithat Gonen,Matvey Brokhin,Gal Omry,James A. Fagin,Ashok R. Shaha +9 more
TL;DR: The data confirm that the newly proposed ATA recurrence staging system effectively predicts the risk of recurrence and persistent disease and can be significantly refined based on the assessment of response to initial therapy, thereby providing a dynamic risk assessment that can be used to more effectively tailor ongoing follow-up recommendations.
Journal ArticleDOI
Prognostic Factors for Persistent or Recurrent Disease of Papillary Thyroid Carcinoma with Neck Lymph Node Metastases and/or Tumor Extension beyond the Thyroid Capsule at Initial Diagnosis
Sophie Leboulleux,Carole Rubino,Eric Baudin,Bernard Caillou,Dana M. Hartl,Jean Michel Bidart,Jean Paul Travagli,Martin Schlumberger +7 more
TL;DR: An excellent survival rate is highlighted and risk classifications of persistent and recurrent disease based on the numbers of LN metastases and ECE-LN, LN Metastases location, tumor size, and thyroglobulin level are suggested.
Journal ArticleDOI
Consensus Statement on the Terminology and Classification of Central Neck Dissection for Thyroid Cancer
Sally E. Carty,David S. Cooper,Gerard M. Doherty,Quan-Yang Duh,Richard T. Kloos,Susan J. Mandel,Gregory W. Randolph,Brendan C. Stack,David L. Steward,David J. Terris,Geoffrey B. Thompson,Ralph P. Tufano,R. Michael Tuttle,Robert Udelsman +13 more
TL;DR: Central neck dissection at a minimum should consist of removal of the prelaryngeal, pretracheal, and paratracheAL lymph nodes.