Solid Lipid Nanoparticle for the Delivery of Docetaxel: A Review
TLDR
The use of SLN for the delivery of Docetaxel to tumor site have several benefits like site specific delivery, less toxic effect, more cell cytotoxicity and more bioavaibility which leads to decrease in the dosing frequency.Abstract:
Solid lipid nanoparticles are the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research. Due to its solid state it has greater stability than other nanocarrier systems. There are several other advantages like sustained release, improves bioavaibility and delivery of poorly water soluble drugs, helps in control of several pharmacokinetic parameters of drugs due to which use of SLN is increasing day by day. Various techniques can be used for the formulation of SLN i.e. solvent evaporation, microemulsification technique, high pressure homogenization and supercritical fluid method. It has several applications likes it is use in gene transfer therapy, also use in different drug delivery systmer like oral and pulmonary drug delivery system. Due to several advantages SLNs are widely used in chemotherapy for the treatment of the cancer. The use of SLN for the delivery of Docetaxel to tumor site have several benefits likes site specific delivery, less toxic effect, more cell cytotoxicity and more bioavaibility which leads to decrease in the dosing frequency. Docetaxel is an anticancer agent extracted from plant Taxus Baccata which is widely used in chemotherapy to treat cancer. This article contains the detail information of about the advantages, disadvantages, different method of preparation and several SLN loaded with Docetaxel.
Keywords: Solid lipid nanoparticles, drug delivery, clinical medicine, poorly water soluble drugsread more
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Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line.
TL;DR: Flow‐cytometry revealed a noteworthy rise in the subG1 peak of the cell cycle in the cancer cells treated with SLNs compared to the controls, indicating apoptosis in cancer cells, and results showed discolouration in SLNs‐treated cells, which further confirmed the induction of apoptosis and the toxicity of the SLNs against MCF‐7 cells.
References
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Journal Article
Solid lipid nanoparticles: a review
TL;DR: A broad treatment of solid lipid nanoparticles is presented discussing their aims, production procedures, advantages, limitations and their possible remedies, as well as appropriate analytical techniques for the characterization of SLN.
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The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma
TL;DR: Results implied that this targeted nanocarrier of docetaxel could enhance its antitumor effect in vivo with low systemic toxicity for the treatment of locally advanced and metastatic HCC.
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Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake
TL;DR: Tween 80-emulsified SLNs showed enhanced intestinal absorption, lymphatic uptake, and relative oral bioavailability of docetaxel compared with Taxotere in rats, and it is worth noting that these surface-modified SLNs may serve as efficient oral delivery systems for docetxel.
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Application of novel solid lipid nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo.
Carsten Rudolph,Ulrike Schillinger,Aurora Ortiz,Kerstin Tabatt,Christian Plank,Rainer H. Müller,Joseph Rosenecker +6 more
TL;DR: In vivo application of TAT2-SLN gene vectors via jet nebulization increased SLN-based gene expression but was accompanied with DNA degradation, which is suitable to optimize gene transfer in vitro.