Journal ArticleDOI
Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.
TLDR
In this article, a trialkoxy-diphenyl-methylester and amide linkage for solid-phase peptide synthesis with Fmoc strategy is described, which can be smoothly cleaved with weak acid, resulting in fragments with intact side-chain protection.About:
This article is published in Tetrahedron Letters.The article was published on 1987-01-01. It has received 859 citations till now. The article focuses on the topics: Peptide synthesis & Solid-phase synthesis.read more
Citations
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Journal ArticleDOI
Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
Gregg B. Fields,Richard L. Noble +1 more
TL;DR: The great variety of conditions under which Fmoc solid phase peptide synthesis may be carried out represents a truly "orthogonal" scheme, and thus offers many unique opportunities for bioorganic chemistry.
Journal ArticleDOI
A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.
TL;DR: Synthesis and cleavage of 10 peptides demonstrated the complementarity of Fmoc chemistry with Reagent K for efficient synthesis of complex peptides and assessed the relative effectiveness of various scavengers in suppressing side reactions.
Journal ArticleDOI
The “One-Bead-One-Compound” Combinatorial Library Method
TL;DR: 1. Small Molecule Libraries 420 1. Acyclic Libraries 422 2. Libraries on Preformed Scaffolds 422 3. Heterocyclic Libraries 423 4. Structurally Heterogeneous Libraries 427 E. Cleavable Linkers 428 1. Single Cleavables 428 2. Multiply Cleavably Linkers 429 IV. Screening Methods 432
Journal ArticleDOI
An unnatural biopolymer
Charles Y. Cho,Edmund J. Moran,Sara Cherry,James C. Stephans,Stephen P. A. Fodor,Cynthia L. Adams,Arathi Sundaram,Jeffrey W. Jacobs,Peter G. Schultz +8 more
TL;DR: Oligocarbamates and other unnatural polymers may provide new frameworks for drug development and for testing theories of protein and peptide folding and structure.
Book ChapterDOI
Solid-phase peptide synthesis.
TL;DR: It is a privilege to be able to contribute to this volume in which Professor Zervas’ friends, students, and colleagues have joined together to honor him and his remarkable contributions to peptide chemistry.
References
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Journal ArticleDOI
A new acid-labile anchor group for the solid-phase synthesis of C-terminal peptide amides by the Fmoc method.
TL;DR: The synthesis of the new polymeric support of type 7 for the preparation of C-terminal peptide amides by the Fmoc method is described and Cleavage of the peptideAmides is performed by very mild acidolysis.