Journal ArticleDOI
Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse.
Verne M. Chapman,Thomas B. Shows +1 more
TLDR
The X linkage of loci coding for glucose-6-phosphate de-hydrogenase (G6PD), hypoxanthine-ph phosphoribosyl transferase (HPRT), and phosphoglycerate kinase (PGK) has been determined for the mouse species Mus musculus and M. caroli.Abstract:
THE X linkage of loci coding for glucose-6-phosphate de-hydrogenase (G6PD), hypoxanthine-phosphoribosyl transferase (HPRT), and phosphoglycerate kinase (PGK) has been determined for the mouse species Mus musculus and M. caroli. Evidence was obtained from a somatic cell genetic analysis of cultured embryonic cells of an interspecific hybrid foetus. The X-chromosomal assignment of these loci has been determined already for several other mammalian species. This evidence was obtained from genetic analyses of electrophoretic variants1 and enzyme deficiencies2,3; from the expression of these genes in viable interspecific hybrids4–6; from somatic cell genetic analyses of heterozygotes7–9, and from the expression of these loci in interspecific somatic cell hybrids10.read more
Citations
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Journal ArticleDOI
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation
TL;DR: The data support a direct role for Xist in the initiation of X inactivation, and the earliest Xist expression in morulae and blastocysts is imprinted, resulting in specific expression of the paternal Xist allele.
Journal ArticleDOI
Human Bone Marrow Mesenchymal Stem Cell Behaviors on PCL/Gelatin Nanofibrous Scaffolds Modified with A Collagen IV-Derived RGD-Containing Peptide
Ali Mota,Abbas Sahebghadam Lotfi,Jalal Barzin,Mostafa Hatam,Behzad Adibi,Zahra Khalaj,Mohammad Massumi +6 more
TL;DR: This peptide modified nanofibrous scaffold can be a promising biomaterial for tissue engineering and regenerative medicine with the use of hBMSCs.
Book ChapterDOI
Mammalian X chromosome inactivation.
TL;DR: The initial step in mammalian sexual differentiation is based on the XX: XY chromosomal system, and a single X chromosome is active in the female soma so as to eliminate gross aneuploidy effects between males and females; this is the broad outline of mammalian X-chromosome regulation.
Journal ArticleDOI
Comparative map for mice and humans.
Joseph H. Nadeau,Muriel T. Davisson,Donald P. Doolittle,Patricia Grant,Alan L. Hillyard,Michael Kosowsky,Thomas H. Roderick +6 more
TL;DR: This report summarizes the status of this comparative map and provided a listing of homologous genes and anonymous loci that have been mapped in mice and humans together with references documenting homology and the chromosomal and linkage assignments.
Journal ArticleDOI
X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro
Gail R. Martin,Charles J. Epstein,Bruce Travis,Georgianne Tucker,Shaul Yatziv,Shaul Yatziv,David W. Martin,S M Clift,Sara Cohen +8 more
TL;DR: Evidence is presented that both X chromosomes are genetically active in clonal cultures of undifferentiated female mouse teratocarcinoma stem cells derived from a spontaneous ovarian tumour.
References
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Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
Journal ArticleDOI
Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.
TL;DR: Application of the methods described in this paper as a tool for quantitative study of normal mammalian cell growth, physiology, genetics, and biochemistry, and the response of cells to drugs, viruses, high energy radiation, and other agents have been indicated.
Journal ArticleDOI
X-chromosome inactivation and developmental patterns in mammals
TL;DR: The review considers information from mammalian embryology relevant to X‐chromosome inactivation, and from X‐inactivation relevant to mammalian embryologists, to derive conclusions about inactivation and its role in embryology.
Journal ArticleDOI
Patterns of Copulatory Behavior in Male Mammals
TL;DR: A schema for systematic inquiry into different patterns of copulatory behavior in male mammals i proposed, based on four attributes, which includes thrusting during intromissions, multiple intromission, and multiple ejaculations.