Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro
Allan Munck,Truls Brinck-Johnsen +1 more
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TLDR
Binding of glucocorticoids and related steroids to rat thymus cells in vitro has been measured by equilibrium and kinetic methods, adding to the evidence that the hormonally active form of cortisol is cortisol itself.About:
This article is published in Journal of Biological Chemistry.The article was published on 1968-11-10 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Antiglucocorticoid & Glucocorticoid.read more
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Steroid receptor interactions with heat shock protein and immunophilin chaperones.
William B. Pratt,David O. Toft +1 more
TL;DR: A historical perspective on a body of steroid receptor research dealing with the structure and physiological significance of the untransformed 9S receptor is provided, and it is shown that hsp90 itself exists in a variety of native multiprotein heterocomplexes independent of steroid receptors and other 'substrate' proteins.
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Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
TL;DR: This review has summarized the multiple endogenous and exogenous factors that have been shown to be involved in this signaling cascade and, thus, to alter glucocorticoid sensitivity.
Journal ArticleDOI
Lipocortin and the mechanism of action of the glucocorticoids
TL;DR: The field of glucocorticoid pharmacology has 'fallen into such neglect' and seems to be connected with early ideas about the function of these hormones, and to a certain extent, with misconceptions about the nature of the inflammatory response itself.
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Tissue effects of glucocorticoids.
John D. Baxter,Peter H. Forsham +1 more
TL;DR: As with cyclic AMP and other types of steroids, glucocorticoids may play a more important role in fetal cellular and tissue differentiation than previously appreciated.
References
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Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.
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Enzymatic and metabolic adaptations in animals.
Journal ArticleDOI
Hormonal control of lymphatic structure and function
TL;DR: The mechanisms by which adrenal cortical hormones produce their important effects on their specific target cells, lymphocytes are focused on.
Journal ArticleDOI
Metabolic Site and Time Course of Cortisol Action on Glucose Uptake, Lactic Acid Output, and Glucose 6-Phosphate Levels of Rat Thymus Cells in Vitro
TL;DR: These results are interpreted as showing that cortisol produces a block at the level of glucose transport or phosphorylation, or both, in rat thymus cells exposed under aerobic conditions to a glucose pulse.
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Steroid-binding properties and stabilization of cytoplasmic glucocorticoid receptors from rat thymus cells.
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