Journal ArticleDOI
Specific high-affinity saturable binding of [3H] Ro5-4864 To benzodiazepine binding sites in the rat cerebral cortex
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This article is published in European Journal of Pharmacology.The article was published on 1981-04-24. It has received 240 citations till now. The article focuses on the topics: Ro5-4864 & PK-11195.read more
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Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair.
Ming-Kai Chen,Tomás R. Guilarte +1 more
TL;DR: The latest evidence suggests that TSPO may not only serve as a biomarker of active brain disease but also the use of T SPO-specific ligands may have therapeutic implications in brain injury and repair.
Journal ArticleDOI
Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function.
TL;DR: Because of their abundance in peripheral tissues and in order to distinguish them from the GABAA or central benzodiazepine receptors, this class of benzodi...
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Agonist and antagonist benzodiazepine receptor interaction in vitro
Hanns Möhler,J. G. Richards +1 more
TL;DR: 3H-Ro 15-1788 interacts with the same number of BR sites as the agonist 3H-clonazepam in various brain regions, but their mode of receptor interaction is different and the thermodynamics of agonist and antagonist receptor interaction are different, but only at temperatures above 21 °C.
Journal ArticleDOI
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies.
G. Le Fur,M.L. Perrier,Nadine Vaucher,F. Imbault,A. Flamier,J. Benavides,Andre Uzan,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy +9 more
TL;DR: In this article, a new compound, chemically unrelated to benzodiazepines, which is a potent inhibitor of [ 3 H] R05-4864 in vitro is also very effective after I.P. injection and oral administration.
References
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Journal ArticleDOI
Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding
TL;DR: Specific [3H]diazepam binding to membranes appears to be restricted to brain, where it is unevenly distributed: the density of diazepam receptors is about five times higher in cortex (the highest density) than in pons-meddula (lowest density).
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Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors
TL;DR: It is proposed that two biochemically distinct BDZ receptors exist in brain which are responsible for the mediation of different pharmacological activities.
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High affinity renal [3H]flunitrazepam binding: Characterization, localization, and alteration in hypertension
TL;DR: Evidence that the renal benzodiazepine binding site is of high affinity, is specific, has a unique distribution, and is regulated during hypertension suggests that it may be associated with an important pathophysiologic structure.