Journal ArticleDOI
Sperm chromatin damage impairs human fertility
Marcello Spanò,Jens Peter Bonde,Henrik Hjøllund,Henrik A Kolstad,Eugenia Cordelli,Giorgio Leter +5 more
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TLDR
The SCSA emerged as a predictor of the probability to conceive in this population-based study and Optimal sperm chromatin packaging seems necessary for full expression of the male fertility potential.About:
This article is published in Fertility and Sterility.The article was published on 2000-01-01. It has received 688 citations till now. The article focuses on the topics: Sperm & Sperm motility.read more
Citations
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Journal ArticleDOI
Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques.
Journal ArticleDOI
Role of sperm chromatin abnormalities and DNA damage in male infertility
Ashok Agarwal,Tamer M. Said +1 more
TL;DR: Screening for sperm DNA damage may provide useful information in cases of male idiopathic infertility and in those men pursuing assisted reproduction, and treatment should include methods for prevention of spermDNA damage.
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Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome
Mona Bungum,Peter Humaidan,Anna Axmon,Marcello Spanò,Leif Bungum,Juris Erenpreiss,Aleksander Giwercman +6 more
TL;DR: DFI can be used as an independent predictor of fertility in couples undergoing IUI and all infertile men should be tested with SCSA as a supplement to the standard semen analysis, when DFI exceeds 30%, ICSI should be the method of choice.
Journal ArticleDOI
Antioxidants for male subfertility
Marian Showell,Rebecca Mackenzie-Proctor,Julie Brown,Anusch Yazdani,Marcin T Stankiewicz,Roger Hart +5 more
TL;DR: This Cochrane review aimed to evaluate the effectiveness and safety of oral supplementation with antioxidants for subfertile male partners in couples seeking fertility assistance with a placebo, no treatment or another antioxidant.
Journal ArticleDOI
The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development.
TL;DR: High loads of DNA damage measured by the Comet assay were predictive of failure of embryo development after ICSI, and it is likely that sperm with DNA damage contributed to successful fertilization and in-vitro development.
References
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Book
Applied Logistic Regression
David W. Hosmer,Stanley Lemeshow +1 more
TL;DR: Hosmer and Lemeshow as discussed by the authors provide an accessible introduction to the logistic regression model while incorporating advances of the last decade, including a variety of software packages for the analysis of data sets.
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Applied Logistic Regression.
TL;DR: Applied Logistic Regression, Third Edition provides an easily accessible introduction to the logistic regression model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables.
Journal ArticleDOI
Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic
Donald P. Evenson,Lorna K. Jost,D Marshall,M J Zinaman,E D Clegg,K Purvis,P. De Angelis,O P Claussen +7 more
TL;DR: Based on logistic regression, spermatozoa with denatured DNA (cells outside the main population, COMP alpha t) were the best predictor for whether a couple would not achieve pregnancy.
Journal ArticleDOI
Relation of mammalian sperm chromatin heterogeneity to fertility.
TL;DR: Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility.
Journal ArticleDOI
Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro.
TL;DR: Since extremely poor semen samples are the indication for intracytoplasmic sperm injection, there is a high likelihood that sperm with fragmented DNA may be selected by chance and used for oocyte injection, resulting in poor fertilization and/or cleavage rates.