Journal ArticleDOI
Spironolactone release from liquisolid formulations prepared with Capryol™ 90, Solutol® HS-15 and Kollicoat® SR 30 D as non-volatile liquid vehicles.
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TLDR
The liquid vehicles used within spironolactone liquisolid formulations enhanced drug dissolution rate and demonstrated that there were no significant changes in the formulations after storage.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2013-02-01. It has received 62 citations till now. The article focuses on the topics: Dissolution testing.read more
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Liquisolid technique and its applications in pharmaceutics
TL;DR: In this paper, the authors present an overview of the use of liquisolid technique in pharmaceutics, and summarize the progress of its applications in the field of drug development.
Journal ArticleDOI
Liquisolid systems and aspects influencing their research and development.
Barbora Vraníková,Jan Gajdziok +1 more
TL;DR: Specific aspects connected with the formulation of liquisolid systems are clarified: properties of excipients (surface area, absorption capacity), variables related to the processing (solubility, liquid load factor) and dosage form evaluation.
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Liquisolid technology applied to pellets: Evaluation of the feasibility and dissolution performance using felodipine as a model drug
Bianca Ramos Pezzini,André O'Reilly Beringhs,Humberto Gomes Ferraz,Marcos Antonio Segatto Silva,Hellen Karine Stulzer,Diva Sonaglio +5 more
TL;DR: The enhanced dissolution rates were attributed to the decrease in disintegration time of the pellets associated with the liquisolid microenvironment triggered by the non-volatile solvents.
Journal ArticleDOI
Norfloxacin as a model hydrophobic drug with unique release from liquisolid formulations prepared with PEG200 and Synperonic PE/L-61 non-volatile liquid vehicles
TL;DR: Increasing the percentage of liquid vehicle in the prepared norfloxacin liquisolid formulations does not necessarily lead to increase in the Percentage of the drug release in distilled water dissolution medium.
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Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts
TL;DR: In this paper, the role of liquisolid technique in improving dissolution of high dose Progesterone was investigated, and results of liquid load factor and liquid retention potential demonstrated a role of Neusilin US2 and Syloid 244 FP as a superior carrier and coat material respectively.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
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Dependence of Reaction Velocity upon Surface and Agitation
A. W. Hixson,J. H. Crowell +1 more
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Natural binders and solid bridge type binding mechanisms in briquettes and pellets made from corn stover and switchgrass.
TL;DR: It was found that activating (softening) the natural binders using moisture and temperature in the range of glass transition is important to make durable particle-particle bonding.