Christian Leuner

TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.

TL;DR: This study presents a meta-analysis of the phytochemical properties of seven novel drugs that have been developed over a period of several years and show promise in terms of protecting against adverse events and promoting drug safety.

TL;DR: It was concluded that biorelevant media should contain sodium as the major cation species to better reflect the physiology and it is prudent in relevant situations to run an additional dissolution test in a modified fed state simulated intestinal fluid (FeSSIF) (or fasted state simulated intestine fluid (FaSSIF), where applicable) containing alternative buffer species.

TL;DR: Solid dispersions of itraconazole and HPMC do not form a homogeneous phase and the influence of water on the phase separation is found.