Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Yali Jia,Ou Tan,Jason Tokayer,Benjamin Potsaid,Y. Wang,Jonathan J. Liu,Martin F. Kraus,Hrebesh M. Subhash,James G. Fujimoto,Joachim Hornegger,David Huang +10 more
TLDR
In this paper, a split-spectrum amplitude-decorrelation angiography (SSADA) was proposed to improve the signal-to-noise ratio (SNR) of flow detection.Abstract:
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.read more
Citations
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Measurement of intraocular distances by backscattering spectral interferometry
TL;DR: In this article, the diffraction tomography theorem is adapted to one-dimensional length measurement and the resulting spectral interferometry technique is described and the first length measurements using this technique on a model eye and on a human eye in vivo are presented.
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Optical coherence tomography angiography.
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Image artifacts in optical coherence tomography angiography.
TL;DR: Because of the quantity of data available and the potential for artifacts, physician interaction in viewing the image data will be required, much like what happens in modern radiology practice.
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Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration
Yali Jia,Steven T. Bailey,David J. Wilson,Ou Tan,Michael L. Klein,Christina J. Flaxel,Benjamin Potsaid,Benjamin Potsaid,Jonathan J. Liu,Chen D. Lu,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: Optical coherence tomography angiography provides depth-resolved information and detailed images of CNV in neovascular AMD and provides more distinct vascular network patterns that were less obscured by subretinal hemorrhage.
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Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.
Amir H. Kashani,Chieh-Li Chen,Jin Kyu Gahm,Fang Zheng,Grace M. Richter,Philip J. Rosenfeld,Yonggang Shi,Ruikang K. Wang +7 more
TL;DR: The methods used to create OCTA images, the practical applications of OCTA in light of invasive dye‐imaging studies (e.g. fluorescein angiography) and clinical studies demonstrating the utility of OCT a for research and clinical practice are discussed.
References
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Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Journal ArticleDOI
Sensitivity advantage of swept source and Fourier domain optical coherence tomography
TL;DR: Results are presented which demonstrate the superior sensitivity of swept source (SS) and Fourier domain (FD) optical coherence tomography (OCT) techniques over the conventional time domain (TD) approach.
Journal ArticleDOI
Performance of fourier domain vs. time domain optical coherence tomography.
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Journal ArticleDOI
Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
Johannes F. de Boer,Barry Cense,B. Hyle Park,Mark C. Pierce,Guillermo J. Tearney,Brett E. Bouma +5 more
TL;DR: A signal-to-noise ratio (SNR) analysis is presented for optical coherence tomography (OCT) signals in which time-domain performance is compared with that of the spectral domain.
Journal ArticleDOI
Measurement of intraocular distances by backscattering spectral interferometry
TL;DR: In this paper, the diffraction tomography theorem is adapted to one-dimensional length measurement and the resulting spectral interferometry technique is described and the first length measurements using this technique on a model eye and on a human eye in vivo are presented.