Journal ArticleDOI
Stability evaluation and sensitive determination of antiviral drug, valacyclovir and its metabolite acyclovir in human plasma by a rapid liquid chromatography-tandem mass spectrometry method.
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TLDR
A simple, sensitive and high throughput liquid chromatography/positive-ion electrospray ionization mass spectrometry (LC-ESI-MS/MS) method has been developed and successfully applied to a bioequivalence study in 41 healthy human subjects after oral administration of 1000 mg valacyclovir tablet formulation under fasting condition.About:
This article is published in Journal of Chromatography B.The article was published on 2009-03-15. It has received 41 citations till now. The article focuses on the topics: Selected reaction monitoring & Liquid chromatography–mass spectrometry.read more
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Incurred sample reanalysis (ISR): a decisive tool in bioanalytical research
TL;DR: Five troubleshooting cases encountered in the analyses of incurred samples for bioanalytical methods developed in the laboratory for mesalamine, hydrochlorothiazide, clopidogrel, sildenafil and rabeprazole are summarized to help develop more reliable and efficient bio Analytical methods.
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Therapeutic drug monitoring of anti-infective agents in critically ill patients.
TL;DR: The available evidence on the use of therapeutic drug monitoring in critically ill patient populations for a number of anti-infective agents, including aminoglycosides, β-lactams, glycopeptides, antifungals and antivirals, and the potential utility of TDM to improve treatment outcome in critical ill patients with severe infections is discussed.
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Analysis of the antiviral drugs acyclovir and valacyclovir-hydrochloride in tsetse flies (Glossina pallidipes) using LC–MSMS
TL;DR: The method was applied in experiments on the mass rearing of tsetse flies for sterile insect technique (SIT) applications, in which the flies were fed with blood meals containing acyclovir or valcyclovir-HCl prior to analysis to assess effects on Glossina pallidipes Salivary Gland Hypertrophy syndrome.
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Simultaneous and sensitive detection of acetaminophen and valacyclovir based on two dimensional graphene nanosheets
TL;DR: In this article, a highly sensitive electrochemical sensor, based on two-dimensional (2D) graphene nanosheets, for the simultaneous detection of acetaminophen and valacyclovir has been developed.
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Carbon nanotube based electrochemical sensor for the sensitive detection of valacyclovir.
TL;DR: The electrochemical sensor developed in this study has strong potential to be employed in the quality control testing of pharmaceutical products and also for therapeutic drug monitoring in hospitals.
References
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Journal ArticleDOI
The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds.
TL;DR: A post-column infusion system was developed in order to analyze suppression of electrospray ionization (ESI) tandem mass spectrometry response in the presence of endogenous plasma interferences and demonstrated that ESI response suppression is compound dependent.
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Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers.
Stephen Weller,M. Robert Blum,Marna Doucette,Thimysta C. Burnette,Donna M. Cederberg,Paulo de Miranda,M Lynn Smiley +6 more
TL;DR: The favorable safety profile and enhanced acyclovir bioavailability from valaciclovir administration has prompted additional clinical evaluations for zoster and herpes simplex virus treatment, as well as cytomegalovirus suppression in immunocompromised patients.
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Valaciclovir : A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections
Caroline M. Perry,Diana Faulds +1 more
TL;DR: Valaciclovir represents and advance in antiherpes drug therapy and is a useful treatment option for patients with herpes zoster or genital herpes.
Journal ArticleDOI
Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy.
TL;DR: Because optimal levels of acyclovir are achieved with a simpler dosing regimen of valacyClovir, compliance may be improved in many patients, thus reducing the incidence of resistant virus.
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Pharmacokinetics of famciclovir in man
M. A. Pue,L. Z. Benet +1 more
TL;DR: The results of a number of studies conducted in healthy volunteers indicate that famciclovir possesses excellent pharmacokinetic properties for the provision of clinically useful concentrations of the antiviral agent pencic Lovir in the oral treatment of herpesviral infections.