Journal ArticleDOI
Stereochemistry of the remote oxidative cyanation of methylcyclohexanones
E. I. Troyanskii,V. V. Mizintsev,V. V. Samoshin,A. I. Lutsenko,V. A. Svyatkin,G. I. Nikishin +5 more
TLDR
In the Na2S2O8-NaCN system, the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically.Abstract:
1.
During the oxidative cyanation of 2-, 3-, and 4-methylcyclohexanones in the Na2S2O8-NaCN system the corresponding 4-cyano(methyl)cyclohexanones are formed regiospecifically.
2.
The oxidative cyanation of 2- and 3-methylcyclohexanones takes place diastereoselectively with the formation of trans- and cis-4-cyano-2(3)-methylcyclohexanones in a ratio of 1.5∶1 (or 2∶1). The selectivity of cyanation is determined by the bridge structure of the intermediate 4-oxo(methyl)cyclohexyl radicals, which are the precursors of the 4-cyanocyclohexanones.read more
Citations
More filters
Patent
Compounds and methods for the treatment or prevention of flavivirus infections
Real Denis,Carl Poisson,Sanjoy Kumar Das,Irina Motorina,Rabindra Rej,Constantin G. Yannopoulos,Laval Chan Chun Kong +6 more
TL;DR: In this paper, a method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Patent
Thiophene analogues for the treatment or prevention of flavivirus infections
Laval Chan Chun Kong,Sanjoy Kumar Das,Carl Poisson,Constantin G. Yannopoulos,Guy Falardeau,Louis Vaillancourt,Real Denis +6 more
TL;DR: The present invention relates to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections as discussed by the authors.
Journal ArticleDOI
Stereoselective free radical cycloaddition-macrocyclization in facile synthesis of trans-cyclohexano-fused 12-membered crown thioethers
Emmanuil I. Troyansky,Rustem F. Ismagilov,Vyacheslav V. Samoshin,Yu. A. Strelenko,Dmitry V. Demchuk,Gennady I. Nikishin,Sergey Lindeman,V. N. Khrustalyov,Yu. T. Struchkov +8 more
TL;DR: In this article, a homolytic cycloaddition of dithiols 1,2 derived from trans- and eis-1,2-cyclohexanediols to alkynes, induced by Pr3B-O2, offers an extremely simple approach to trans and cis cyclohexano-fused 12-membered crown thialactones 4a-c-7a c.
References
More filters
Journal ArticleDOI
Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms
TL;DR: An improved force field for molecular mechanics calculations of the structures and energies of hydrocarbons is presented in this paper, where the problem of simultaneously obtaining a sufficiently large gauche butane interaction energy while keeping the hydrogens small enough for good structural predictions was solved with the aid of onefold and twofold rotational barriers.
Journal ArticleDOI
Handbuch der präparativen anorganischen Chemie. Unter Mitarbeit zahlreicher Fachleute herausg. v. G. Brauer. Stuttgart: Ferdinand Enke Verlag 1954. XIX, 1439 S., 318 Abb., Ln. DM 199,—
Journal ArticleDOI
Kernresonanzspektroskopische Konformationsanalyse an Cyclohexanderivaten
H. Feltkamp,N. C. Franklin +1 more
TL;DR: In this paper, the Kernresonanzspektroskopie zur Zeit is considered as one of the best methods for cyclohexanderivaten, erlaubt sowohl die Untersuchung der raumlichen Lage der Substituenten in fixierten Molekulen alas also the bestimmung von Konformationsgleichgewichten an beweglichen Ringen.
Related Papers (5)
Free-radical cyclization of enantiomerically enriched 2-p-tolylthio derivatives of 2-allylcyclohexanones with Mn(III): asymmetric synthesis of bridged bicyclic ketones and thiochroman-3-ones
J.L Garcı́a-Ruano,A Rumbero +1 more