Stroke-Associated Pneumonia: Major Advances and Obstacles
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TLDR
The pathophysiology of SAP is likely explained by aspiration combined with stroke-induced immunodepression through complex humeral and neural pathways that include the hypothalamic-pituitary-adrenal axis, parasympathetic and sympathetic systems.Abstract:
Background: Stroke-associated pneumonia (SAP) has been implicated in the morbidity, mortality and increased medical cost after acute ischemic stroke. The annual cread more
Citations
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Translocation and dissemination of commensal bacteria in post-stroke infection
Dragana Stanley,Linda J. Mason,Kate E. Mackin,Yogitha N. Srikhanta,Dena Lyras,Monica D. Prakash,Kulmira Nurgali,Andres Venegas,Michael D. Hill,Robert J. Moore,Robert J. Moore,Connie H.Y. Wong +11 more
TL;DR: Using high-throughput 16S rRNA gene amplicon sequencing and bioinformatics analyses, evidence is provided demonstrating that the source of the bacteria forming the microbial community in the lungs of post-stroke mice was indeed the host small intestine.
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Postischemic Inflammation in Acute Stroke
TL;DR: This review describes the main phases of the inflammatory process occurring after arterial cerebral occlusion, with an emphasis on the role of single mediators.
Journal ArticleDOI
High Neutrophil-to-Lymphocyte Ratio Predicts Stroke-Associated Pneumonia
Ki Woong Nam,Ki Woong Nam,Tae Jung Kim,Tae Jung Kim,Ji Sung Lee,Hyung-Min Kwon,Hyung-Min Kwon,Yong Seok Lee,Yong Seok Lee,Sang-Bae Ko,Sang-Bae Ko,Byung-Woo Yoon,Byung-Woo Yoon +12 more
TL;DR: It is demonstrated that a higher NLR predicted SAP in patients with acute ischemic stroke, and may help to identify high-risk patients in time and provide clues for further studies about preventive antibiotic therapy.
Journal ArticleDOI
Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.
Sarah Hoffmann,Hendrik J. Harms,Lena Ulm,Darius G. Nabavi,Bruno-Marcel Mackert,Ingo Schmehl,Gerhard J. Jungehulsing,Joan Montaner,Alejandro Bustamante,Marcella Hermans,Frank Hamilton,Jos Göhler,Uwe Malzahn,Carolin Malsch,Peter U. Heuschmann,Christian Meisel,Andreas Meisel +16 more
TL;DR: It is demonstrated that dysphagia and stroke-induced immunodepression syndrome are independent risk factors for stroke-associated pneumonia.
Journal ArticleDOI
How Is Pneumonia Diagnosed in Clinical Stroke Research? A Systematic Review and Meta-Analysis
Amit Kishore,Andy Vail,Ángel Chamorro,Javier Garau,Stephen J. Hopkins,Mario Di Napoli,Lalit Kalra,Peter Langhorne,Joan Montaner,Christine Roffe,Anthony Rudd,Pippa J. Tyrrell,Diederik van de Beek,Mark Woodhead,Andreas Meisel,Craig J. Smith +15 more
TL;DR: A systematic review of existing diagnostic approaches to pneumonia in recent clinical stroke research found considerable variation in terminology and the diagnostic approach to pneumonia, which supports the need for consensus development of operational diagnostic criteria for pneumonia complicating stroke.
References
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Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association
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TL;DR: The American Heart Association's 2020 Impact Goals for Cardiovascular Diseases and Disorders are revealed, with a focus on preventing, treating, and preventing heart disease and stroke.
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CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.
TL;DR: In this paper, the NHSN criteria for all healthcare-associated infections (HAIs) are presented, including those for the "Big Four" (surgical site infection [SSI], pneumonia [PNEU], bloodstream infection [BSI] and urinary tract infection [UTI]).
Journal Article
CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.
TL;DR: In this article, the NHSN criteria for all healthcare-associated infections (HAIs) are presented, including those for the "Big Four" (surgical site infection [SSI], pneumonia [PNEU], bloodstream infection [BSI] and urinary tract infection [UTI]).
Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Ventilator-associated pneumonia.
Jean Chastre,Jean-Yves Fagon +1 more
TL;DR: Appropriate antimicrobial treatment of patients with VAP significantly improves outcome, more rapid identification of infected patients and accurate selection of antimicrobial agents represent important clinical goals.