Journal ArticleDOI
Structural properties of nonionic surfactant/glycerol/paraffin lyotropic liquid crystals
TLDR
In this article, the authors formulate and study two component or multicomponent compositions with a relatively low Brij 96V content, liquid paraffin, glycerol and water for therapeutic purposes, and the liquid crystals were examined by polarizing light microscopy and transmission electron microscopic observation of replicas produced by the freeze-fracture technique.Abstract:
Lamellar lyotropic liquid-crystalline systems are thermodynamically stable, optically isotropic and are formed spontaneously. New possibilities for the development of controlled drug delivery systems are inherent in these systems in consequence of their stability and special, skin-friendly structure. The aim was to formulate and study two-component or multicomponent compositions with a relatively low Brij 96V content, liquid paraffin, glycerol and water for therapeutic purposes. The liquid crystals were examined by polarizing light microscopy and transmission electron microscopic observation of replicas produced by the freeze–fracture technique to demonstrate the presence of lamellar liquid-crystalline domains. The existence of a regular structure was determined by X-ray diffraction.read more
Citations
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Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration.
TL;DR: Emphasis is laid on topical applications of the colloidal drug delivery systems (DDS) covered, with the main objective of both sustained drug release and improved stability of DDS.
Journal Article
Self-assembled surfactant nano-structures important in drug delivery: a review.
TL;DR: Drug efficacy depends on the drug loaded into the vehicle, temperature, drug solubility, pH, release characteristics, additives and most significantly, the vehicle morphology, which suggests the same vehicle cannot be used with high efficiency for all types of drugs and locations where the drug delivery has to take place.
Journal ArticleDOI
An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: the influence of colloidal structure on emulsions skin hydration potential.
Snezana Savic,Milica Lukic,Ivana Jaksic,Stephan Reichl,Slobodanka Tamburic,Christel C. Müller-Goymann +5 more
TL;DR: Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity, as well as the emulsifier/water ratios.
Journal ArticleDOI
Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier
TL;DR: In this paper, the authors examined the lyotropic potential of an alkylpolyglucoside mixed emulsifier (Cetearyl glucoside&Cetaryl alcohol), which belongs to the new generation of natural (sugar) surfactants, and elaborate the potential stabilization mechanism and relation between the colloid microstructure and water distribution within the systems.
Journal ArticleDOI
Liquid crystal nanoparticles for commercial drug delivery
TL;DR: The study suggests that LC-based nanoparticles have the potential to revolutionize drug delivery industry, however a reliable method for production of nanoparticles on a large scale needs to be explored further.
References
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Book
Micelles, Membranes, Microemulsions, and Monolayers
TL;DR: Ben-Shaul et al. as discussed by the authors studied the thermodynamic properties of Amphiphile Self-Assembly and showed that the growth, flexibility and polymorphism of Micellar Liquid Crystals in dilute solutions can be explained by the geometrical foundations of Mesomorphic Polymorphism.
Journal ArticleDOI
Surfactant association structure and emulsion stability
TL;DR: In this paper, the influence of the presence of liquid crystals at the o/w interface on the flocculation and coalescence of emulsion droplets was estimated from the change in van der Waals (VdW) interaction.
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Cubic phases for studies of drug partition into lipid bilayers.
TL;DR: The studies reveal that the time needed to reach partition equilibrium was substantially reduced by decreasing the amount of cubic phase, increasing the interfacial area between the cubic phase and the aqueous phase, and increasing the temperature and the agitation of the sample.
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Rheological behaviour of a lamellar liquid crystalline surfactant–water system
TL;DR: In this paper, the rheological behavior of a lamellar liquid crystalline surfactant-water system was investigated using a Haake RS-100 viscometer, and the results were analyzed on the basis of Jones-McLeish slipplane theory.
Journal ArticleDOI
Formation of fine three-phase emulsions by the liquid crystal emulsification method with arginine β-branched monoalkyl phosphate
TL;DR: In this article, a new emulsification method using a liquid crystalline phase of an ionic surfactant, l -arginine β-branched monoalkyl phosphate (R6R10MP-1Arg), which is hardly affected by temperature, has been developed.