Journal ArticleDOI
Studies on the Pathogenesis of Dengue Infection in Monkeys. I. Clinical Laboratory Responses to Primary Infection
Reads0
Chats0
TLDR
Virologic, serologic, and clinical responses to infection were studied in monkeys inoculated with dengue 1-4 viruses and no abnormalities were observed in serial hematocrit, prothrombin time, and determinations of total protein.Abstract:
Virologic, serologic, and clinical responses to infection were studied in 122 Macaca mulatta monkeys and 17 monkeys of three other species that were inoculated with dengue 1-4 viruses passaged in tissue culture. Susceptible rhesus monkeys, inoculated with either high (1037-10".pfu) or low (8-50 pfu) doses of virus always developed antibody. Frequently with dengue 2 infection, but less frequently with dengue 1 infection, lymphadenomegaly, depression of leukocyte count, and lymphocytosis were noted. In approximately 90% of infected animals viremia began two to six days after inoculation; 90% of dengue 2 and 4 viremias lasted six days or less; the average duration of dengue 1 viremia was somewhat longer, and of dengue 3 viremia shorter than this. HAI titers to the homologous antigen in convalescent sera were usually twofold higher than titers to heterologous dengue viruses; antibody response to dengue 4 infection was relatively specific. No abnormalities were observed in serial hematocrit, prothrombin time, and determinations of total protein. Levels of complement in serum rose several days after the start of serial bleedings in both infected and control animals. The courses of infection due to dengue viruses are similar in humans and monkeys.read more
Citations
More filters
Journal ArticleDOI
Dengue and Dengue Hemorrhagic Fever
TL;DR: A review of the changing epidemiology of dengue and hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both Dengue fever and DVF, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control can be found in this paper.
Dengue and dengue hemorrhagic fever.
TL;DR: A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
Journal ArticleDOI
Dengue and dengue hemorrhagic fever
TL;DR: Control of dengue at the present time is dependent on control of the principal vector mosquito, A. aegypti, and indigenous transmission in the continental United States remains a public health concern.
Journal ArticleDOI
Dengue and dengue haemorrhagic fever
José G. Rigau-Pérez,Gary G. Clark,Duane J. Gubler,Paul Reiter,Eduard J. Sanders,A. Vance Vorndam +5 more
TL;DR: The geographical expansion of DHF presents the need for well-documented clinical, epidemiological, and virological descriptions of the syndrome in the Americas, and biological and social research are essential to develop effective mosquito control, medications to reduce capillary leakage, and a safe tetravalent vaccine.
Journal ArticleDOI
Dengue Virus Pathogenesis: an Integrated View
TL;DR: A personalized approach to the study of pathogenesis will elucidate the basis of individual risk for development of DHF and DSS as well as identify the genetic and environmental bases for differences in risk forDevelopment of severe disease.
References
More filters
Journal ArticleDOI
Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.
D H Clarke,J Casals +1 more
TL;DR: A description of the procedures currently in use in The Rockefeller Foundation Virus Laboratories, some of which were initially developed elsewhere; of those developed in this laboratory, most aspects have not been previously reported.
Journal ArticleDOI
Research on dengue during World War II.
TL;DR: Dengue research was brought from the field into the laboratory and further progress has been made possible by work on experimental animals instead of on human volunteers, and a great deal more was learned about the basic properties of the dengue viruses.
Journal ArticleDOI
Dengue and Chikungunya Virus Infection in Man in Thailand, 1962–1964: I. Observations on Hospitalized Patients with Hemorrhagic Fever
Journal ArticleDOI
Viruses Associated with Epidemic Hemorrhagic Fevers of the Philippines and Thailand
TL;DR: It was discovered that viruses of previously recognized types and of closely related new types apparently have etiologic roles in a new and highly dangerous epidemic disease syndrome.
Journal ArticleDOI
Dengue and chikungunya virus infection in man in Thailand, 1962-1964. IV. Epidemiologic studies in the Bangkok metropolitan area.
TL;DR: Observations suggest a low level of anthropophilia in these species in Thailand and the possibility of a biological barrier to transmission of arboviruses by them to man.