Journal ArticleDOI
Studies on the synthesis and unusual behavior of vinyl sulfone-modified hexenopyranosylthymines
TLDR
Although vinyl sulfone-modified- (VSM) pent-2'-enofuranosyl nucleosides 2 and hex-2-enopyranosyl glycoside 4 are easily synthesized from the corresponding mesylated sulfones 1c and 3c, via an oxidation-mesylation-elimination route, the 3'-C-sulfonyl-hex-3'-enopyrsylthymine 11 is not obtained from 10 and a glycalAbout:
This article is published in Carbohydrate Research.The article was published on 2008-05-19. It has received 1 citations till now. The article focuses on the topics: Glycal & Sulfone.read more
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Synthesis of β-mono- and β,γ-di-substituted α-methylene-γ-lactams
Alexis Hernández-Guadarrama,Fernando Cuevas,Iris Janet Montoya-Balbas,Perla Román-Bravo,Irma Linzaga-Elizalde +4 more
TL;DR: In this paper , a series of β-mono- and β,γ-di-substituted α-methylene-γ-lactams was synthesized.
References
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Journal ArticleDOI
Vinyl sulfones : Synthetic preparations and medicinal chemistry applications
TL;DR: This review includes traditional methods used for the synthesis of vinyl sulfones, but focuses mainly on newer reactions applied to vinyl sulfone, including olefin metathesis, conjugate reduction, asymmetric dihydroxylation (AD), and the use of Vinyl sulfones to arrive at highly functionalized targets, all illustrating the rich and versatile chemistry this group can efficiently perform.
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New syntheses of 2',3'-dideoxy-2',3'-di-substituted & -2'-mono-substituted uridines & adenosines by michael addition reactions
TL;DR: Compounds described herein, with free 5'-hydroxyl function, are potential inhibitors of the HIV-reverse transcriptase promoted c-DNA synthesis.
Journal ArticleDOI
Oxepane nucleic acids : Synthesis, characterization, and properties of oligonucleotides bearing a seven-membered carbohydrate ring
David Sabatino,Masad J. Damha +1 more
TL;DR: OT15 was found to elicit Escherichia coli RNase H-mediated degradation of the rA15 strand, and ONAs are useful tools for biological studies and provide new insights into the structure and function of natural and alternative genetic systems.
Journal ArticleDOI
De novo asymmetric synthesis of homoadenosine via a palladium-catalyzed N-glycosylation.
TL;DR: A highly stereoselective synthesis of l-2-deoxy-beta-ribo-hexopyranosyl nucleosides from 6-chloropurine and Boc-protected pyranone has been developed using a palladium-catalyzed N-glycosylation, diastereoselectives reduction, and reductive 1,3-transposition.