Journal ArticleDOI
Styryl-lactone derivatives and alkaloids from Goniothalamus borneensis (Annonaceae)
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TLDR
Twelve natural products, including two new compounds, were isolated from the bark of the Malaysian tree Goniothalamus borneensis and evaluated for their cytotoxic activity, including goniothalesdiol 1a and goniothalactam 2, which were elucidated by spectroscopy including 2D-NMR spectroscopic.About:
This article is published in Tetrahedron.The article was published on 1998-03-05. It has received 74 citations till now. The article focuses on the topics: Goniothalamus & Annonaceae.read more
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Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities
TL;DR: Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines, which are reviewed and classified on the basis of their oxygenation pattern.
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Cytotoxic activity of ( S )-goniothalamin and analogues against human cancer cells
TL;DR: Non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth and compound 8 as the more potent against breast cancer cells with resistance phenotype for adryamycin (NCIADR).
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Styryl-lactones from Goniothalamus species— A review
TL;DR: In this paper, thirty-one bioactive styryl-lactones, with six different basic skeletons, have been isolated from Goniothalamus species, and various aspects of their isolation, structural elucidation, biogenesis and biological activity are reviewed.
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Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells
TL;DR: The results demonstrate that goniothalamin-induced apoptosis occurs via the mitochondrial pathway in a caspase dependent manner.
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Naturally occurring aristolochic acid analogues and their toxicities
Johanna Michl,Martin Ingrouille,Monique S. J. Simmonds,Monique S. J. Simmonds,Michael Heinrich,Michael Heinrich +5 more
TL;DR: In vivo and in vitro toxicity and mutagenicity of these three classes of compounds are discussed and the review gives an update of aristolochic acids, aristolactams and 4,5-dioxoaporphines reported between 2003 and 2013 and their biological activities.
References
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Journal ArticleDOI
Goniothalenol: a novel, bioactive, tetrahydrofurano-2-pyrone from (annonaceae)
A.Atef Ebrabim El-Zayat,Nelson R. Ferrigni,Thomas G. McCloud,Ann T. McKenzie,Stephen R. Byrn,John M. Cassady,Ching-Jer Chang,Jerry L. McLaughlin +7 more
TL;DR: In this article, a fractionation of the stem bark of the title plant of the Goniothalenol (I) was used for bioactivity monitoring with brine lethality.
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Goniothalamin oxide: An embryotoxic compound from (annonaceae)
T.W Sam,Chew Sew-Yeu,Sabirin Matsjeh,E.K Gan,Dzulkifli Abdul Razak,Abdul Latiff Mohamed,Abdul Latiff Mohamed +6 more
TL;DR: Goniothalamin (1) and its oxide (2) have been isolated as the active embryotoxic and teratogenic components of the title plant as discussed by the authors, and their structure has been established from its spectral data and its synthesis together with an isomer (3) by epoxidation of goniothalamina.
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Cytotoxicity and electron microscopy of cell death induced by goniothalamin
Abdul M. Ali,Muhammad Mukram Mohamed Mackeen,Muhajir Hamid,Q. B. Aun,Y. Zauyah,H. L P Azimahtol,Kazuyoshi Kawazu +6 more
TL;DR: The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells.
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Gonioheptolides A and B: Novel eight-membered-ring lactones from Goniothalamus giganteus (Annonaceae)
Xing-Ping Fang,Jon E. Anderson,Xiao-xing Qiu,John F. Kozlowski,Ching-Jer Chang,Jerry L. McLaughlin +5 more
TL;DR: Two novel eight-membered-ring lactones, gonioheptolides A and B, have been isolated from the bark of Goniothalamus giganteus and showed marginal cytotoxicities to certain human solid tumor cells in culture.
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Phenanthrene lactams from Goniothalamus velutinus
Siraj Omar,Chang Leng Chee,Fasihuddin B. Ahmad,Jiu Xiang Ni,Hasan Jaber,Jinasheng Huang,Tetsuo Nakatsu +6 more
TL;DR: A new phenanthrene lactam, designated as velutinam (10amino-8-hydroxy-3,4-dimethoxyphenanthrene-1-carboxylic acid lactam), was isolated from an extract of the bark of Goniothalamus velutinus as mentioned in this paper.