Journal ArticleDOI
Subcellular localization of serotonin in an identified serotonin-containing neurone.
TLDR
There is strong evidence that the amine acts as a transmitter on one particular type of neurone in the gastropod brain and the precise type of particle or particles associated with serotonin is not definitely known.Abstract:
KNOWLEDGE of the subcellular localization of serotonin (5-hydroxytryptamine) in neurones is important for an understanding of the precise physiological role of this amine in nervous tissue. Some of the most pertinent pharmacological and electrophysiological data on the neuronal role of serotonin have been obtained from work with molluscs1,2. In particular there is strong evidence that the amine acts as a transmitter on one particular type of neurone in the gastropod brain2. Fractionation studies with homogenates of bivalve ganglia, which are extremely rich in serotonin, have shown that the amine is bound to particles, but associated with particles of different density from those binding acetylcholine3. The precise type of particle or particles associated with serotonin, however, is not definitely known4.read more
Citations
More filters
Journal ArticleDOI
Mapping of nerve cells in the suboesophageal ganglia of Helix aspersa.
TL;DR: The axons from some cells have been traced following intracellular injections of CoCl2 and precipitation of CoS, which supported the electrophysiological method of tracing axons by recording antidromic spikes in the cell body following stimulation of a peripheral nerve.
Journal ArticleDOI
Mapping of serotonin-like immunoreactivity in the lobster nervous system.
TL;DR: A map of the system of serotonin-immunoreactive cell bodies, fibers, and nerve endings is constructed, and a dense plexus of nerve endings showing serotonin-like immunoreactivity surrounds each of the thoracic second roots in the vicinity of groups of peripheral neurosecretory neurons.
Book ChapterDOI
Octopamine and some related noncatecholic amines in invertebrate nervous systems.
Harold A. Robertson,A.V. Juorio +1 more
TL;DR: This chapter reviews octopamine and some related noncatecholic amines in invertebrate nervous systems and finds that microamines have long been known to be pharmacologically active and whether they interact with receptors and, if so, how.
Journal ArticleDOI
Homology of the giant serotonergic neurons (metacerebral cells) in Aplysia and pulmonate molluscs
TL;DR: It was concluded that the giant cerebral serotonin-containing neurons of Aplysia and of pulmonate molluscs are true homologues and extended the known distribution of these neurons to a second major subclass (Opisthobranchiata) of mollsuscs.
Journal ArticleDOI
Chemical, enzymatic and ultrastructural characterization of 5-hydroxytryptamine-containing neurons from the ganglia of Aplysia californica and Tritionia diomedia.
TL;DR: The cytoplasm of 5‐HT cell bodies in Aplysia and Tritonia characteristically contains granules that have minimum diameters of approx.
References
More filters
Journal Article
p-CHLOROPHENYLALANINE: A SPECIFIC DEPLETOR OF BRAIN SEROTONIN
B K Koe,A Weissman +1 more
TL;DR: The results suggest that p -chlorophenylalanine may effect 5HT depletion by inhibiting the biosynthesis of this monoamine, possibly by blocking tryptophan hydroxylation.
Journal Article
Blockade of endogenous norepinephrine synthesis by alpha-methyl-tyrosine, an inhibitor of tyrosine hydroxylase.
TL;DR: Preliminary studies of the pharmacologic consequences of blockade of norepinephrine synthesis indicate impairment of motor activity and mild sedation in cats and guinea pigs and a reduction of the tyramine and nore Pinephrine pressor responses in guinea pig and rats.
Journal ArticleDOI
The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines a review on the methodology
Hans Corrodi,Gösta Jonsson +1 more
TL;DR: The histochemical fluorescence method of Falck and Hillarp as discussed by the authors for the demonstration of biogenic monoamines is based on the finding that the amines can be condensed with formaldehyde to yield strongly fluorescent compounds, provided that they are enclosed in a dried protein layer, as in freezedried or air-dried tissues.
Journal ArticleDOI
Anomalous rectification in the metacerebral giant cells and its consequences for synaptic transmission
E. R. Kandel,L. Tauc +1 more
TL;DR: In the central neurones that have so far been examined the passive electrical properties of the extrasynaptic membrane has been shown to be relatively constant in the subthreshold range, but excitatory synaptic potentials produced by chemical transmission tend to vary in amplitude with changes in membrane potential.
Related Papers (5)
Synaptic connexions of two symmetrically placed giant serotonin-containing neurones.
G. A. Cottrell,J. B. Macon +1 more