Journal ArticleDOI
Surveillance for Congenital Cytomegalovirus Disease: A Report from the National Congenital Cytomegalovirus Disease Registry
TLDR
Compared with 1990 birth statistics in the United States, mothers of infants with congenital CMV disease were younger, and a greater percentage of these mothers were black, which may reflect different modes of transmission and suggest target populations for future CMV vaccine initiatives.Abstract:
A national surveillance program for congenital cytomegalovirus (CMV) disease was initiated in 1990. In 4 years 285 cases were reported without seasonal patterns. Mean birth statistics were as follows: gestational age, 36 weeks; weight, 2,224 g; length, 45 cm; and head circumference, 30 cm. Of the infants 68% had CNS involvement, which was significantly (P or = 3 mg/dL, petechiae, an alanine aminotransferase level of > 100 U/L, a platelet count of < or = 75,000/mm3, hepatomegaly, and splenomegaly (P < .05). Maternal demographics revealed that the mean age was 23 years (range, 13-38 years), 59% were white, 33% were black, 47% had low incomes (receiving Medicaid), and 45% were primiparous. Compared with 1990 birth statistics in the United States, mothers of infants with congenital CMV disease were younger, and a greater percentage of these mothers were black. Two distinct maternal groups were identified on the basis of age, socioeconomic status, and parity. This finding may reflect different modes of transmission and suggest target populations for future CMV vaccine initiatives.read more
Citations
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Journal ArticleDOI
Sensorineural hearing loss in children
TL;DR: Establishment of vaccination programmes for several vaccine-preventable infectious diseases would reduce rates of acquired SNHL and focused genetic counselling and health education might lead to a decrease in the prevalence of inherited SNHL in these countries.
Journal ArticleDOI
Viral infections during pregnancy.
TL;DR: The major viral infections relevant to pregnancy are reviewed and potential mechanisms for the associated adverse pregnancy outcomes are offered.
Journal ArticleDOI
Vaccine Development to Prevent Cytomegalovirus Disease: Report from the National Vaccine Advisory Committee
John F. Modlin,Ann M. Arvin,Patricia E. Fast,Martin G. Myers,Stanley A. Plotkin,Regina Rabinovich +5 more
TL;DR: Information is summarized about the changing epidemiology of CMV and immune responses to infection and immunity, and the current status of several vaccine candidates are reviewed.
Journal ArticleDOI
Human Cytomegalovirus Infection of Placental Cytotrophoblasts In Vitro and In Utero: Implications for Transmission and Pathogenesis
TL;DR: The observation that CMV infection impairs critical aspects of cytotrophoblast function offers testable hypotheses for explaining the deleterious effects of this virus on pregnancy outcome and suggests two possible routes of CMV transmission to the fetus.
Journal ArticleDOI
Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection
Daniel E. Noyola,Daniel E. Noyola,Gail J. Demmler,Gail J. Demmler,Christopher T. Nelson,Christopher T. Nelson,Carol Griesser,Carol Griesser,W. Daniel Williamson,W. Daniel Williamson,Jane Troendle Atkins,Jane Troendle Atkins,Judith Rozelle,Judith Rozelle,Marie Turcich,Marie Turcich,Antolin M. Llorente,Antolin M. Llorente,Sherry Sellers-Vinson,Sherry Sellers-Vinson,Ann Reynolds,Ann Reynolds,James F. Bale,James F. Bale,Paul Gerson,Paul Gerson,Martha D. Yow,Martha D. Yow +27 more
TL;DR: The presence of microcephaly at birth was the most specific predictor of poor cognitive outcome in children with symptomatic congenital CMV infection, whereas children with normal findings on head CT and head circumference proportional to weight exhibited a good cognitive outcome.
References
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Statistical abstract of the United States
TL;DR: The Red River of the North basin of the Philippines was considered a part of the Louisiana Purchase by the United States Department of Commerce in the 1939 Census Atlas of the United Philippines as discussed by the authors.
Journal ArticleDOI
Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome.
Sergio Stagno,Robert F. Pass,Gretchen A. Cloud,William J. Britt,Ronald E. Henderson,Philip D. Walton,Dean A. Veren,Frank Page,Charles A. Alford +8 more
TL;DR: Primary CMV infection during pregnancy poses a 30% to 40% risk of intrauterine transmission and adverse outcome is more likely when infection occurs within the first half of gestation.
Journal ArticleDOI
Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality
TL;DR: It is concluded that neonates with symptomatic congenital CMV infection have a multi-system disease with significant morbidity and mortality.
Journal ArticleDOI
Infectious diseases society of america and centers for disease control : summary of a workshop on surveillance for congenital cytomegalovirus disease
TL;DR: A national system for surveillance of congenital CMV disease was established; its goals are to characterize trends over time, to identify risk groups, and to lay the groundwork for evaluation of future intervention programs.