Susceptibility of Bacteroides fragilis to Six Antibiotics Determined by Standardized Antimicrobial Disc Susceptibility Testing
TLDR
The susceptibility of 100 or more strains of Bacteroides fragilis to six antibiotics was determined by standardized agar dilution and disc diffusion tests, and good correlation of results was obtained with chloramphenicol, clindamycin, lincomycin, penicillin, and vancomYcin.Abstract:
The susceptibility of 100 or more strains of Bacteroides fragilis to six antibiotics was determined by standardized agar dilution and disc diffusion tests. Good correlation of results of the two methods was obtained with chloramphenicol, clindamycin, lincomycin, penicillin, and vancomycin. Correlation of results with erythromycin was not as good. A great deal of overlapping of zone diameters among strains classed as susceptible, intermediate, and resistant occurred with both erythromycin and lincomycin, making interpretation of disc diffusion tests difficult. All strains tested were susceptible to chloramphenicol; 94% were susceptible to clindamycin at concentrations readily achieved with ordinary dosage, and all strains were inhibited by 6.2 μg/ml, a level which is achieved with somewhat more intensive therapy. Only 7% were shown to be susceptible to erythromycin and 13% to lincomycin under the conditions of our testing procedure. Only a small percentage of the strains were susceptible to penicillin, and none was susceptible to vancomycin.read more
Citations
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Susceptibility of Anaerobic Bacteria to 23 Antimicrobial Agents
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Statistical Theory and Methodology in Science and Engineering
TL;DR: Brownlee as discussed by the authors is the author of Industrial Experimentation, a book which has long been popular in the United Kingdom and differs from most in offering adequate proofs using 'easy' mathematics.
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Evaluation of the E test for susceptibility testing of anaerobic bacteria.
TL;DR: The susceptibilities of 105 clinical isolates of anaerobic bacteria were determined by a new method, the E test, and were compared with the MICs for these organisms obtained by the reference agar dilution method by using supplemented brucella and Wilkins-Chalgren agars.
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Susceptibility Tests of Anaerobic Bacteria: Statistical and Clinical Considerations
Carl M. Metzler,Ray M. DeHaan +1 more
TL;DR: A bivariate "error rate-bounded" classification scheme is proposed for relating minimal inhibitory concentration and zone size of bacteria, which gives the minimal error of misclassification with the known data on zone diameter and minimal inhibitionory concentration.
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Medium for use in antibiotic susceptibility testing of anaerobic bacteria.
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Journal ArticleDOI
Statistical Theory and Methodology in Science and Engineering
TL;DR: Brownlee as discussed by the authors is the author of Industrial Experimentation, a book which has long been popular in the United Kingdom and differs from most in offering adequate proofs using 'easy' mathematics.