Journal ArticleDOI
Synergy research: approaching a new generation of phytopharmaceuticals.
TLDR
Gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs and the main targets were found to be COX 1+2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family.About:
This article is published in Fitoterapia.The article was published on 2011-01-01. It has received 420 citations till now.read more
Citations
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Journal ArticleDOI
The Essential Medicinal Chemistry of Curcumin
Kathryn M. Nelson,Jayme L. Dahlin,Jonathan Bisson,James G. Graham,Guido F. Pauli,Michael A. Walters +5 more
TL;DR: Evidence is provided that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead and, on the basis of this in-depth evaluation, potential new directions for research onCurcuminoids are discussed.
Journal ArticleDOI
Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
TL;DR: Particular focus will be placed on phytocannabinoid‐terpenoid interactions that could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin‐resistant Staphylococcus aureus).
Journal ArticleDOI
A status review on the medicinal properties of essential oils
TL;DR: A review of the bio-active properties of essential oils and their medicinal potential is presented in this article. But, the review is limited to essential oils extracted from plants by steam distillation and various solvents.
Journal ArticleDOI
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2.
Lindsay K. Caesar,Nadja B. Cech +1 more
TL;DR: This report represents a critical review with commentary about the current state of the scientific literature as it relates to studying combination effects in natural product extracts, with particular emphasis on analytical and Big Data approaches for identifying synergistic or antagonistic combinations and elucidating the mechanisms that underlie their interactions.
Journal ArticleDOI
The pharmaceutical industry and natural products: historical status and new trends
TL;DR: This review presents an industrial perspective discussing natural product drug discovery, lead research, botanicals, pro-drugs, synergy effects, drugs interactions with botanical, traditional medicines, reverse pharmacognosy and presents the difficulties in accessing biodiversity.
References
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Journal Article
What is synergy
TL;DR: In this paper, the authors examined the effect of pool walking on renal function in pregnant women and found that the renin-angiotensin-aldosterone levels were suppressed during pool walking, resulting in higher total urine volume and creatinine clearance.
Journal ArticleDOI
Synergy research: approaching a new generation of phytopharmaceuticals.
TL;DR: This review describes many examples of how modern molecular-biological methods can enable us to understand the various synergistic mechanisms underlying these effects of herbal drug combinations.
Journal ArticleDOI
Synergy and other interactions in phytomedicines.
TL;DR: Positive and negative aspects of interactions are discussed together with the methods used to identify and measure synergy, and the evidence is divided into experimental, in vitro instances, as well as clinical examples where available.
Journal ArticleDOI
Synergism between natural products and antibiotics against infectious diseases
TL;DR: The observed synergy and mechanism of action between natural products including flavonoids and essential oils and synthetic drugs in effectively combating bacterial, fungal and mycobacterial infections is described.
Journal ArticleDOI
Drugs, their targets and the nature and number of drug targets
TL;DR: This work considers the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles it provides an estimation of the total number of current drug targets.
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Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more