Journal ArticleDOI
Drugs, their targets and the nature and number of drug targets
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This work considers the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles it provides an estimation of the total number of current drug targets.Abstract:
What is a drug target? And how many such targets are there? Here, we consider the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles we provide an estimation of the total number of current drug targets.read more
Citations
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How many drug targets are there
TL;DR: A consensus number of current drug targets for all classes of approved therapeutic drugs is proposed, and an emerging realization of the importance of polypharmacology and also the power of a gene-family-led approach in generating novel and important therapies is highlighted.
Journal ArticleDOI
DrugBank: a knowledgebase for drugs, drug actions and drug targets
David S. Wishart,Craig Knox,An Chi Guo,Dean Cheng,Savita Shrivastava,Dan Tzur,Bijaya Gautam,Murtaza Hassanali +7 more
TL;DR: The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release and contains 60% more FDA-approved small molecule and biotech drugs including 10% more ‘experimental’ drugs.
Journal ArticleDOI
Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
Journal ArticleDOI
Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
Journal ArticleDOI
Artificial intelligence in radiology
Ahmed Hosny,Chintan Parmar,John Quackenbush,Lawrence H. Schwartz,Lawrence H. Schwartz,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts +6 more
TL;DR: A general understanding of AI methods, particularly those pertaining to image-based tasks, is established and how these methods could impact multiple facets of radiology is explored, with a general focus on applications in oncology.
References
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5-Fluorouracil: mechanisms of action and clinical strategies
TL;DR: This work has shown that novel genes identified in DNA microarray profiling have the potential to identify novel genes that are involved in mediating resistance to 5-FU, and these genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to5-FU-based chemotherapy.
Journal ArticleDOI
The druggable genome
Andrew L. Hopkins,Colin R. Groom +1 more
TL;DR: An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry.
Journal ArticleDOI
Cisplatin: mode of cytotoxic action and molecular basis of resistance
TL;DR: The molecular signature defining the resistant phenotype varies between tumors, and the number of resistance mechanisms activated in response to selection pressures dictates the overall extent of cisplatin resistance.
Journal ArticleDOI
Prostanoid Receptors: Structures, Properties, and Functions
TL;DR: An overview of the current status of research on the prostanoid receptors is given and domains and amino acid residues conferring the specificities of ligand binding and signal transduction are being clarified.
Patent
High throughput screen
TL;DR: In this paper, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity was proposed, and a method for monitoring ion channel activity in a membrane.