Synthesis and Reactions of New 4-Oxo-4H-benzopyran-3-carboxaldehydes Containing Hydroxy Groups or 2-Oxopyran Cycles
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In this paper, the synthesis of 8 hydroxy-and 2-oxopyranochromone-3-carboxaldehydes 3, 5 and their reactions with 2-hydroxyaniline, 2,4-dinitrophenylhydrazine and 2-benzothiazolyl hydrazine were investigated.Abstract:
The synthesis of eight hydroxy- and 2-oxopyranochromone-3-carboxaldehydes 3, 5 and their reactions with 2-hydroxyaniline, 2,4-dinitrophenylhydrazine and 2-benzothiazolylhydrazine were investigated. Products were confirmed by IR, NMR spectral and elemental analysis data. The semi-empirical AM1 quantum-chemical method has been used to study optimal geometries and heats of formation of synthesized 3-formylchromones.read more
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Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.
TL;DR: The parent 3-formylchromone and 3-methyl-7-hydroxychromone were found to be inactive and the structures of the compounds were elucidated by using spectroscopic techniques, including (1)H NMR, EI MS, IR, UV and elemental analysis.
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3-Formylchromones: potential antiinflammatory agents.
Khalid Mohammed Khan,Nida Ambreen,Uzma Rasool Mughal,Saima Jalil,Shahnaz Perveen,M. Iqbal Choudhary +5 more
TL;DR: Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities and SAR has been discussed in this report.
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Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment.
TL;DR: Amongst the synthesized compounds 7d, 7e, 7f and 7h were found to possess activity against methicillin-resistant S. aureus in addition to the activity against other bacterial strains such as E. faecalis, S. pneumoniae, and E. coli.
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Lewis Base Catalyzed [4+2] Annulation of Electron‐Deficient Chromone‐Derived Heterodienes and Acetylenes
TL;DR: An asymmetric synthesis of the tricyclic benzopyrones was developed by using modified cinchona alkaloids as enantiodifferentiating Lewis base catalysts.
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A chromone analog inhibits TNF-alpha induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kappaB activation.
Sarvesh Kumar,Brajendra K. Singh,Brajendra K. Singh,Anil K. Pandey,Ajit Kumar,Sunil K. Sharma,Hanumantharao G. Raj,Ashok K. Prasad,Erik V. Van der Eycken,Virinder S. Parmar,Balaram Ghosh +10 more
TL;DR: To elucidate the molecular mechanism of inhibition of cell adhesion molecules, the status of nuclear transcription factor-kappaB was investigated and it was established that compound 8a significantly blocked the TNF-alpha induced activation of NF-k KappaB.
References
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Studies on antianaphylactic agents—III
TL;DR: By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.
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44. Aluminium chloride, a new reagent for the condensation of β-ketonic esters with phenols. Part I. The condensations of methyl β-resorcylate, β-resorcylic acid, and resacetophenone with ethyl acetoacetate
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Infrared spectra and theoretical study of methyl, formyl and acetyl derivatives of chromones
Hafen Mohamad El-Metwally El-Shaaer,Alexander Perjéssy,Pavol Zahradník,Margita Lácová,Zora Šusteková +4 more
TL;DR: In this paper, the C=O stretching frequencies of substituted 2-methylchromones (3a, 3j), 2-formyl chromones (4a, 4j), 3-acetyl-2-methyl-6i, 4a, 5a, 6i, and 6a were measured in CCl4 and CHCl3 and correlated with σ+ substituent constants.
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Study of Microwave Irradiation Effect on Condensation of 6-R-3-Formylchromones with Active Methylene Compounds
Renata Gašparová,Margita Lácová +1 more
TL;DR: Condensation of 6-R-3-formylchromones with 3,3dimethyl-1,3-cyclohexanedione (II), 1,3indandione (III), 1 2e-biindenylidene-3,1e,3e-trione (bindone, IV ), 2oxo-1 4-benzothiazine (V ) and 3-oxo2,3dihydro-1-thia-3a,8-diazacyclopent[a]indene (
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Study of Substituted Formylchromones
TL;DR: In this paper, substitutions bonded to the aromatic nucleus have only small effect on the electron structure of the pyrone ring and the calculated charges on the carbon atoms correlate well with the experimental 13 C chemical shifts.