Journal ArticleDOI
Synthesis of Sulphur Compounds: Regioselective Synthesis of Thieno[2,3-b]thiophenes by Sulfoxide Rearrangement
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TLDR
A number of thieno[2,3-b]thiophenes have been successfully synthesized in a 50-55% yield by m-chloroperoxybenzoic acid-mediated tandem cyclization involving [2, 3] and [3, 3]-sigmatropic rearrangements and an intramolecular Michael addition as discussed by the authors.Abstract:
A number of thieno[2,3-b]thiophenes have been successfully synthesized in a 50–55% yield by m-chloroperoxybenzoic acid–mediated tandem cyclization involving [2, 3] and [3, 3] sigmatropic rearrangements and an intramolecular Michael addition.read more
Citations
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Journal ArticleDOI
A Novel Radical Cyclization Approach to Thieno‐Fused Heterocycles
TL;DR: In this paper, an efficient synthesis of novel aryl/heteroaryl-substituted thieno-fused heterocycles, that is, Thieno[2,3b]thiophenes, thienon[ 2,3-b]indoles, and pyrazolo[3,2-c]-thiophenses, involving radical-mediated cyclization of 2-(2-bromohetero-aryl)-3-methylthio-3-aryl/heteronitriles has been reported.
Book ChapterDOI
Thiophenes and their Benzo Derivatives: Synthesis
O. Sato,J. Nakayama +1 more
TL;DR: In this paper, the advances in the synthetic methods of thiophenes and their benzo derivatives are discussed, in many cases according to the final reaction leading to the thiophene nucleus but not the starting materials since this permits a more clear-cut classification.
References
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Journal ArticleDOI
Synthesis of various 5‐substituted uracils
TL;DR: In this article, the Suzuki Pd(0)-catalyzed coupling between arylboronic acids and bromides or iodides in weakly alkaline medium was evaluated.
Journal ArticleDOI
New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.
John D. Prugh,George D. Hartman,Pierre Mallorga,B. M. Mckeever,Michelson,Murcko Mark A,Harvey Schwam,Robert L. Smith,John M. Sondey,James P. Springer +9 more
TL;DR: A series of 5-substituents were varied to maximize both inhibitory potency against carbonic anhydrase and water solubility and to minimize pigment binding in the iris in topical ocular hypotensive activity in glaucoma models.
Journal ArticleDOI
Efficient one pot preparation of variously substituted thieno [2,3‐b] thiophene
Alain Cornel,Gilbert Kirsch +1 more
TL;DR: In this article, an efficient one pot access to variously substituted thieno[2,3-b]thiophene is described, and the title compounds were obtained from 1,3dicarbonyl or equivalent compounds, carbon disulfide and halomethyl derivatives in good to high yields and fully characterized.
Journal ArticleDOI
Ketenderivate, IV. Neue Thiophene und Thieno[2.3‐b]thiophene
TL;DR: In this paper, Uber Reaktionen (Acylierung, Diazotierung, Kondensation mit Aldehyden, Synthese von Thieno-pyrimidinen) wird berichtet.
Journal ArticleDOI
Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid.
Stjepan Kukolja,Susan E. Draheim,Bernard J. Graves,David C. Hunden,Janice L. Pfeil,Robin D. G. Cooper,John L. Ott,F. T. Counter +7 more
TL;DR: In vitro testing of these new cephalosporins indicates good activity against Gram-positive bacteria and against Streptococcus pneumoniae infections compound 25 displayed better mouse protection than cephalexin.
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