T1rho relaxation mapping in human osteoarthritis (OA) cartilage: comparison of T1rho with T2.
TLDR
To quantify the spin‐lattice relaxation time in the rotating frame (T1ρ) in various clinical grades of human osteoarthritis cartilage specimens obtained from total knee replacement surgery, and to correlate the T1ρ with OA disease progression and compare it with the transverse relaxation time (T2).Abstract:
Purpose
To quantify the spin-lattice relaxation time in the rotating frame (T1ρ) in various clinical grades of human osteoarthritis (OA) cartilage specimens obtained from total knee replacement surgery, and to correlate the T1ρ with OA disease progression and compare it with the transverse relaxation time (T2).
Materials and Methods
Human cartilage specimens were obtained from consenting patients (N = 8) who underwent total replacement of the knee joint at the Pennsylvania Hospital, Philadelphia, PA, USA. T2- and T1ρ-weighted images were obtained on a 4.0 Tesla whole-body GE Signa scanner (GEMS, Milwaukee, WI, USA). A 7-cm diameter transmit/receive quadrature birdcage coil tuned to 170 MHz was employed.
Results
All of the surgical knee replacement OA cartilage specimens showed elevated relaxation times (T2 and T1ρ) compared to healthy cartilage tissue. In various grades of OA specimens, the T1ρ relaxation times varied from 62 ± 5 msec to 100 ± 8 msec (mean ± SEM) depending on the degree of cartilage degeneration. However, T2 relaxation times varied only from 32 ± 2 msec to 45 ± 4 msec (mean ± SEM) on the same cartilage specimens. The increase in T2 and T1ρ in various clinical grades of OA specimens were ∼5–50% and 30–120%, respectively, compared to healthy specimens. The degenerative status of the cartilage specimens was also confirmed by histological evaluation.
Conclusion
Preliminary results from a limited number of knee specimens (N = 8) suggest that T1ρ relaxation mapping is a sensitive noninvasive marker for quantitatively predicting and monitoring the status of macromolecules in early OA. Furthermore, T1ρ has a higher dynamic range (>100%) for detecting early pathology compared to T2. This higher dynamic range can be exploited to measure even small macromolecular changes with greater accuracy compared to T2. Because of these advantages, T1ρ relaxation mapping may be useful for evaluating early OA therapy. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.read more
Citations
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Osteoarthritis: an update with relevance for clinical practice
TL;DR: In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease, and treatment targeted more specifically at these phenotypes might lead to improved outcomes.
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In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Xiaojuan Li,C. Benjamin Ma,Thomas M. Link,Darwin-Dean Castillo,Gabrielle Blumenkrantz,Jesus Lozano,Julio Carballido-Gamio,Michael D. Ries,Sharmila Majumdar +8 more
TL;DR: The ability to detect early cartilage degeneration prior to morphologic changes may allow us to critically monitor the course of OA and injury progression, and to evaluate the success of treatment to patients with early stages of Oa.
Journal ArticleDOI
T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients—a 3.0-Tesla MRI study
Robert Stahl,Robert Stahl,Anthony Luke,Xiaojuan Li,Julio Carballido-Gamio,C. Benjamin Ma,Sharmila Majumdar,Thomas M. Link +7 more
TL;DR: T1rho and T2 could be a parameter suited to identify active healthy subjects at higher risk for developing cartilage pathology, as well as in patients with early osteoarthritis (OA), which showed a high prevalence of focal cartilage abnormalities.
Journal ArticleDOI
Quantitative MRI using T1ρ and T2 in human osteoarthritic cartilage specimens: Correlation with biochemical measurements and histology
Xiaojuan Li,Jonathan Cheng,Katrina Lin,Ehsan Saadat,Radu Bolbos,B. Jobke,Michael D. Ries,Andrew E. Horvai,Thomas M. Link,Sharmila Majumdar +9 more
TL;DR: Quantitative MRI has a great potential to provide noninvasive imaging biomarkers for cartilage degeneration in osteoarthritis, and the correlation between imaging parameters, biochemical contents and histological scores was studied.
Journal ArticleDOI
Advances in Imaging of Osteoarthritis and Cartilage
TL;DR: Although MR imaging is the most important modality in imaging of OA and cartilage, others such as ultrasonography play a complementary role that will be discussed briefly.
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