Journal ArticleDOI
Tandem Anionic oxy-Cope Rearrangement/Oxygenation Reactions as a Versatile Method for Approaching Diverse Scaffolds.
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TLDR
Tandem anionic oxy-Cope rearrangement/radical oxygenation reactions provide diverse δ,ε-unsaturated α-(aminoxy) carbonyl compounds that serve as convenient scaffolds to diverse compound classes.Abstract:
Tandem anionic oxy-Cope rearrangement/radical oxygenation reactions provide δ,ϵ-unsaturated α-(aminoxy) carbonyl compounds, which serve as convenient precursors to diverse compound classes. Functionalized carbocycles are accessible by very rare all-carbon 5-endo-trig cyclizations, but also common 5-exo-trig radical cyclizations, based on the persistent radical effect. The tandem reactions can be further extended by highly diastereoselective allylation or reduction steps to give complex scaffolds.read more
Citations
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A computer algorithm to discover iterative sequences of organic reactions
Karol Molga,Sara Szymkuć,Patrycja Gołębiowska,Oskar Popik,Piotr Dittwald,Martyna Moskal,Rafał Roszak,Jacek Mlynarski,Bartosz A. Grzybowski +8 more
TL;DR: In this article , a computer algorithm using a comprehensive knowledge base of individual reactions constructs and evaluates myriads of putative, but chemically plausible, sequences and discovers an unprecedented number of iterative sequences.
Journal ArticleDOI
Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones
TL;DR: In this paper , a Cu-catalyzed 5-endo-selective trifluoromethyl carbocyclization of ynones is developed for the concise synthesis of trifloromet-hylated cyclopentenones.
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Unified Total Synthesis of Diverse Meroterpenoids from Ganoderma Applanatum.
TL;DR: A unified approach to meroterpenoids applanatumols B, V, W, X, and Y produced by the medicinal fungus Ganoderma and 2'-epi-spiroapplanatumine O is presented in this paper .
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A Photocatalytic System Composed of Benzimidazolium Aryloxide and Tetramethylpiperidine 1-Oxyl to Promote Desulfonylative α-Oxyamination Reactions of α-Sulfonylketones
Tsukasa Tanaka,Takehiro Kiuchi,Yu Ooe,Hajime Iwamoto,Shin-ya Takizawa,Shigeru Murata,Eietsu Hasegawa +6 more
TL;DR: In this article , a new photocatalytic system was developed for carrying out desulfonylative α-oxyamination reactions of α-sulfonylsketones in which α-ketoalkyl radicals are generated.
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Etherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C-F Bond Cleavage.
TL;DR: Potassium base-mediated defluoroetherification of aryl and heteroaryl fluorides with alkoxyboronic acid pinacol esters under transition-metal-free conditions is reported in this paper .
References
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Journal ArticleDOI
Rules for ring closure
TL;DR: The endocyclic closure of nucleophilic centres to polarized double bonds to give five-membered rings is impeded by restrictions of geometry; these restrictions can be overcome in acid through the generation of oxonium or protonated forms.
Journal ArticleDOI
The persistent radical effect: a principle for selective radical reactions and living radical polymerizations.
Journal ArticleDOI
Gem-Disubstituent Effect: Theoretical Basis and Synthetic Applications
Michael E. Jung,Grazia Piizzi +1 more
TL;DR: A comparison study of the effects of gem-Dialkyl Substitution in Drug Design on the Formation and Stability of Inorganic and Organometallic Complexes and their implications for synthetic chemistry and drug design.
Journal ArticleDOI
CXIX.—The formation and stability of spiro-compounds. Part I. spiro-Compounds from cyclohexane
Journal ArticleDOI
Nitroxides: applications in synthesis and in polymer chemistry.
Ludger Tebben,Armido Studer +1 more
TL;DR: Alkoxyamines derived from nitroxides are shown to be highly useful precursors of C-centered radicals in synthesis and also in polymer chemistry, and new developments in the synthesis of complex polymer architectures are highlighted.
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