M
Michael E. Jung
Researcher at University of California, Los Angeles
Publications - 578
Citations - 19268
Michael E. Jung is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Total synthesis & Intramolecular force. The author has an hindex of 57, co-authored 574 publications receiving 17596 citations. Previous affiliations of Michael E. Jung include Johns Hopkins University & Cubist Pharmaceuticals.
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Journal ArticleDOI
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Chris Tran,Samedy Ouk,Nicola J. Clegg,Yu Chen,Philip A. Watson,Vivek K. Arora,John Wongvipat,Peter Smith-Jones,Dongwon Yoo,Andrew Kwon,Teresa Wasielewska,Derek S. Welsbie,Charlie D. Chen,Celestia S. Higano,Tomasz M. Beer,David T. Hung,Howard I. Scher,Michael E. Jung,Charles L. Sawyers +18 more
TL;DR: The diarylthiohydantoins RD162 and MDV3100 are characterized, two compounds optimized from a screen for nonsteroidal antiandrogens that retain activity in the setting of increased androgen receptor expression that appear to be promising candidates for treatment of advanced prostate cancer.
The Paris endoscopic classification of superficial neoplastic lesions : esophagus, stomach and colon.
H. Inoue,Hiroshi Kashida,Shin-ei Kudo,M. Sasako,T Shimoda,H Watanabe,Shigeto Yoshida,M. Guelrud,Charles J. Lightdale,Kenneth K. Wang,Robert H. Riddell,Diebold,R Lambert,JF Rey,Michael E. Jung,Horst Neuhaus,A. T. R. Axon,Robert M. Genta,J. J. Gonvers +18 more
TL;DR: An international group of endoscopists, surgeons, and pathologists gathered in Paris for an intensive workshop designed to explore the utility and clinical relevance of the Japanese endoscopic classification of superficial neoplastic lesions of the GI tract.
Journal ArticleDOI
Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair,Jennifer L. S. Willoughby,Amy Chan,Klaus Charisse,Md. Rowshon Alam,Qianfan Wang,Menno Hoekstra,Pachamuthu Kandasamy,Alexander V Kel'in,Stuart Milstein,Nate Taneja,Jonathan O'Shea,Sarfraz Shaikh,Ligang Zhang,Ronald J. van der Sluis,Michael E. Jung,Akin Akinc,Renta Hutabarat,Satya Kuchimanchi,Kevin Fitzgerald,Tracy Zimmermann,Theo J.C. Van Berkel,Martin Maier,Kallanthottathil G. Rajeev,Muthiah Manoharan +24 more
TL;DR: The optimally chemically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to treat a wide range of diseases involving liver-expressed genes.
Journal ArticleDOI
Update on the Paris classification of superficial neoplastic lesions in the digestive tract
A. T R Axon,M. D. Diebold,M. Fujino,R. Fujita,Robert M. Genta,J. J. Gonvers,M. Guelrud,H. Inoue,Michael E. Jung,Hiroshi Kashida,Shin-ei Kudo,René Lambert,Charles J. Lightdale,Takashi Nakamura,Horst Neuhaus,H. Niwa,K. Ogoshi,J. F. Rey,Robert H. Riddell,M. Sasako,Tadakazu Shimoda,Haruhisa Suzuki,G. N. J. Tytgat,Kenneth K. Wang,Hiroshi Watanabe,T. Yamakawa,Shigeto Yoshida +26 more
TL;DR: The morphology of superficial and nonprotruding neoplastic lesions is relevant to the prognosis and is an important criterion for the necessity of additional surgical resection after endoscopic resection.
Journal ArticleDOI
Gem-Disubstituent Effect: Theoretical Basis and Synthetic Applications
Michael E. Jung,Grazia Piizzi +1 more
TL;DR: A comparison study of the effects of gem-Dialkyl Substitution in Drug Design on the Formation and Stability of Inorganic and Organometallic Complexes and their implications for synthetic chemistry and drug design.