Journal ArticleDOI
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
TLDR
It is concluded that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes inatellite cell ultrastructure.Abstract:
Testosterone (T) supplementation in men induces muscle fiber hypertrophy. We hypothesized that T-induced increase in muscle fiber size is associated with a dose-dependent increase in satellite cell...read more
Citations
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Journal ArticleDOI
Satellite Cells and the Muscle Stem Cell Niche
TL;DR: For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.
Journal ArticleDOI
Effects of Androgenic-Anabolic Steroids in Athletes
Fred Hartgens,Harm Kuipers +1 more
TL;DR: Although AAS administration may affect erythropoiesis and blood haemoglobin concentrations, no effect on endurance performance was observed and little data about the effects of AAS on metabolic responses during exercise training and recovery are available and, therefore, do not allow firm conclusions.
Journal ArticleDOI
Muscle wasting in disease: molecular mechanisms and promising therapies
TL;DR: Major advances in the understanding of the cellular mechanisms that regulate the protein balance in muscle include the identification of several cytokines, particularly myostatin, and a common transcriptional programme that promotes muscle wasting.
Journal ArticleDOI
Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway.
TL;DR: The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men.
Journal ArticleDOI
Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle
Shalender Bhasin,Linda J. Woodhouse,Richard Casaburi,Atam B. Singh,R. P. Mac,Martin Lee,Kevin E. Yarasheski,Indrani Sinha-Hikim,Connie Dzekov,Jeanne Dzekov,Lynne Magliano,Thomas W. Storer,Thomas W. Storer +12 more
TL;DR: Older men are as responsive as young men to testosterone's anabolic effects; however, older men have lower testosterone clearance rates, higher increments in hemoglobin, and a higher frequency of adverse effects.
References
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Journal ArticleDOI
The efficiency of systematic sampling in stereology and its prediction
TL;DR: A set of very simple estimators of efficiency are presented and illustrated with a variety of biological examples and a nomogram for predicting the necessary number of points when performing point counting is provided.
A Randomized Double-blind Placebo-controlled Trial
TL;DR: The purpose of the present investigation was to evaluate the safety and effectiveness of the antiviral drug amantadine for the treatment of hepatitis C in those who had either previously failed interferon therapy or were not candidates for interferons.
Book
Practical methods for biological morphometry
TL;DR: This is the first textbook dealing with stereological methods that puts the emphasis on practical versus theoretical stereology, on its use in biology versus in materials sciences and on sampling efficiency versus measuring precision.
Journal ArticleDOI
Myogenic satellite cells: physiology to molecular biology.
Thomas J. Hawke,Daniel J. Garry +1 more
TL;DR: This review will highlight the origin and unique markers of the satellite cell population, the regulation by growth factors, and the response to physiological and pathological stimuli, and identify future research goals for the study of satellite cell biology.