Journal ArticleDOI
Thalamic thermo-algesic transmission: ventral posterior (VP) complex versus VMpo in the light of a thalamic infarct with central pain
Carmen Montes,Michel Magnin,Joseph Maarrawi,Maud Frot,Philippe Convers,François Mauguière,François Mauguière,Luis Garcia-Larrea +7 more
TLDR
The results show that the VP is definitely involved in thermo‐algesic transmission in man, and that its selective lesion can lead to central pain, but also suggest that much of the spino‐thalamo‐cortical volley elicited by painful heat stimuli does not transit through VP, supporting the hypothesis that a non‐VP locus lying more posteriorly in the human thalamus is important for thermo-algesics transmission.Abstract:
The respective roles of the ventral posterior complex (VP) and of the more recently described VMpo (posterior part of the ventral medial nucleus) as thalamic relays for pain and temperature pathways have recently been the subject of controversy. Data we obtained in one patient after a limited left thalamic infarct bring some new insights into this debate. This patient presented sudden right-sided hypesthesia for both lemniscal (touch, vibration, joint position) and spinothalamic (pain and temperature) modalities. He subsequently developed right-sided central pain with allodynia. Projection of 3D magnetic resonance images onto a human thalamic atlas revealed a lesion involving the anterior two thirds of the ventral posterior lateral nucleus (VPL) and, to a lesser extent, the ventral posterior medial (VPM) and inferior (VPI) nuclei. Conversely, the lesion did not extend posterior and ventral enough to concern the putative location of the spinothalamic-afferented nucleus VMpo. Neurophysiological studies showed a marked reduction (67%) of cortical responses depending on dorsal column-lemniscal transmission, while spinothalamic-specific, CO2-laser induced cortical responses were only moderately attenuated (33%). Our results show that the VP is definitely involved in thermo-algesic transmission in man, and that its selective lesion can lead to central pain. However, results also suggest that much of the spino-thalamo-cortical volley elicited by painful heat stimuli does not transit through VP, supporting the hypothesis that a non-VP locus lying more posteriorly in the human thalamus is important for thermo-algesic transmission.read more
Citations
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Journal ArticleDOI
The Cerebral Signature for Pain Perception and Its Modulation
Irene Tracey,Patrick W. Mantyh +1 more
TL;DR: It is suggested that the brainstem plays a pivotal role in gating the degree of nociceptive transmission so that the resultant pain experienced is appropriate for the particular situation of the individual.
Journal ArticleDOI
Recommendations for the clinical use of somatosensory-evoked potentials
Giorgio Cruccu,Michael J. Aminoff,Gabriel Curio,Jean-Michel Guerit,Ryusuke Kakigi,François Mauguière,François Mauguière,Paolo Maria Rossini,Rolf-Detlef Treede,Luis Garcia-Larrea,Luis Garcia-Larrea +10 more
TL;DR: Technical advice is given, normative values are reported, and special clinical applications of somatosensory-evoked potentials are discussed, which are drawing increasing interest.
Journal ArticleDOI
A mean three-dimensional atlas of the human thalamus: generation from multiple histological data.
TL;DR: The results show that integration of multiple stereotactic anatomical data to produce an unbiased, mean model of the thalamic nuclei and their subdivisions is feasible and that the integration reduces problems of atlas reconstruction inherent to histological stacks to a large extent.
Journal ArticleDOI
Nociceptive processing in the human brain.
TL;DR: The result has produced a dramatic shift in thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch.
Journal ArticleDOI
Role of primary somatosensory cortex in the coding of pain.
TL;DR: It is demonstrated that an extreme anterior position within SI (area 3a) receives input originating predominantly from unmyelinated nociceptors, distinguishing it from posterior SI (areas 3b and 1), long recognized as receiving input predominantly from myelinated afferents, including nocICEptors.
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