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The Aging Brain and Senile Dementia

Kalidas Nandy, +1 more
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The article was published on 1977-01-01. It has received 52 citations till now. The article focuses on the topics: Aging brain.

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Association between nutritional status and cognitive functioning in a healthy elderly population

TL;DR: "Subclinical" malnutrition may play a small role in the depression of cognitive function detectable in some elderly individuals, or depressed cognitive function may result in reduced nutrient intake.
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Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain.

TL;DR: It is suggested that aging is a physiological process that occurs asynchronously in different areas of the brain and that the rate of that process is modulated by environmental factors and related to the neuronal-synaptic-molecular substrates of each area.
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Sleep and circadian rhythms in mood disorders

TL;DR: Self‐reported sleep disturbances are present in over 80% of patients with depression, however, sleep electroencephalography findings, based on overnight polysomnography have not always differentiated depressed patients from healthy individuals.
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Changes in Sleep as a Function of Adolescent Development

TL;DR: While changes in sleep across adolescence are a normal part of development, many adolescents are getting insufficient sleep and are consequently, less likely to perform well at school, more likely to develop mood-related disturbances, be obese, and are at greater risk for traffic accidents, alcohol and drug abuse.
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Sleep EEG changes during adolescence: an index of a fundamental brain reorganization.

TL;DR: The data demonstrate that the daytime sleepiness that emerges in adolescence is related to the decline in NREM delta as well as to altered sleep schedules, and provide guideposts for studying cognitive and behavioral correlates of adolescent brain reorganization.
References
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A new and rapid colorimetric determination of acetylcholinesterase activity.

TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
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The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

TL;DR: The expectation of mental disorder shows a steep increase with advancing chronological age, and beyond 75 years a large part of this increase is accounted for by disorders associated with degenerative changes in the central nervous system for which the authors lack remedies at the present time.
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Cerebral blood flow in dementia.

TL;DR: Cerebral blood flow per 100 gm brain per minute was normal in the primary degenerative group but low in the multi-infarct group, suggesting the blood flow is adequate for metabolic needs of the brain in patients withPrimary degenerative dementia but inadequate for those with multi- infarct dementia.
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Fine structural localization of a blood-brain barrier to exogenous peroxidase

TL;DR: These findings localize, at a fine structural level, a "barrier" to the passage of peroxidase at the endothelium of vessels in the cerebral cortex in mice, particularly with reference to a recent study in which similar techniques were applied to capillaries in heart and skeletal muscle.
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Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205–242; (1968) 7, 331–356

TL;DR: This is a series in which key papers in old age psychiatry are presented with an introduction, commentary by the original author and current update by someone working in the field.