Journal ArticleDOI
The anatomical substrate of the turning behaviour seen after lesions in the nigrostriatal dopamine system.
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TLDR
Turning induced by apomorphine in rats lesioned with 6-hydroxydopamine is inhibited by damage to the ipsilateral ventromedial area of thalamus which receives fibres from the substantia nigra.About:
This article is published in Neuroscience.The article was published on 1983-01-01. It has received 38 citations till now. The article focuses on the topics: Substantia nigra & Striatum.read more
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Dopamine and the action of opiates: a reevaluation of the dopamine hypothesis of schizophrenia. With special consideration of the role of endogenous opioids in the pathogenesis of schizophrenia.
TL;DR: It is suggested that the antipsychotic efficacy of opioids in patients suffering from schizophrenia may result from an interaction of opioids with the dopaminergic system, and an imbalance of opiate-DA interaction might be involved in the pathogenesis of schizophrenia.
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Distribution and synaptic contacts of the cortical terminals arising from neurons in the rat ventromedial thalamic nucleus.
TL;DR: Thalamic neurons responding antidromically to only one stimulation site were more common when the stimulation was within motor cortical areas, suggesting that in this region a more restricted pattern of termination is the rule.
Journal ArticleDOI
Clinical and topographic magnetic resonance imaging characteristics of suspected thalamic infarcts in 16 dogs
Rita Gonçalves,Inés Carrera,Laurent Garosi,Peter M. Smith,J. Fraser McConnell,Jacques Penderis +5 more
TL;DR: Sixteen dogs with acute-onset, non-progressive signs of brain dysfunction and magnetic resonance imaging (MRI) characteristics compatible with thalamic infarction are described.
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The rat ventromedial thalamic nucleus and motor control: role of N- methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission
TL;DR: Evidence is provided that an imbalance between NMDA-mediated excitation and GABAergic inhibition within the rat VM leads to disturbances of motility, whereas muscarinic transmission within this nucleus appears to be of minor importance.
References
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Journal ArticleDOI
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
TL;DR: In this article, the effect of L-DOPA and the dopamine receptor stimulating drug apomorphine was studied in rats after unilateral degeneration of the nigrostriatal DA system by intracerebral injection of 6-hydroxydopamine.
Journal ArticleDOI
A method for the combined staining of cells and fibers in the nervous system.
Efferent connections of substantia nigra and ventral tegmental area in the rat
R Beckstead,V Domestick,W Nauta +2 more
TL;DR: Isotope injections confined to the pars reticulata label sparse nigrostriatal fibers, and numerous nigrothalamic fibers ascending mainly to the nucleus ventromedialis and in lesser number to the parafascicular nucleus and the paralamellar zone of the nucleus mediodorsalis.
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Efferent connections of the substantia nigra and ventral tegmental area in the rat
TL;DR: In this paper, small injections of tritiated leucine and proline confined to the ventral tegmental area (AVT) were found to label fibers ascending to the entire ventromedial half of the striatum, but most massively to the medial striatal zone that includes the nucleus accumbens, the thalamus, and the most medial zone of the mediodorsal nucleus.
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Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.
Joseph T. Coyle,Robert Schwarcz +1 more
TL;DR: It is reported that the injection of kainic acid into the rat striatum causes neuronal degeneration, neurochemical alterations and behavioural responses resembling Huntington's chorea, which could provide an animal model for the study of the disease.